Adhesion and transmigration

A more selective inhibition of NFkB can be achieved by transfecting cells with DNA coding for the natural inhibitor IkBo or a mutant IkB protein that lacks 36 N-terminal amino acids, and consequently becomes proteolysis resistant. In this way expression of adhesion molecules and monocyte adhesion and transmigration can be inhibited [87,88], The potentials and limitations of these latter types of therapy are however not fully understood as yet. Different transfection systems (adenoviral, retroviral, non-viral) are available for gene delivery purposes, all with their own potentials and restrictions. 

Klouche M, May A E, Hemmes M, et al. (1999) Enzymatically modified, nonoxidized LDL induces selective adhesion and transmigration of monocytes and T-lymphocytes through human endothelial cell monolayers. Arterioscler ThrombArterioscler Thromb Vase Biol 19 784-793... 

Kahler, C.M., Pischel, A., Kaufmann, G., and Wiedermann, C.J. (2001). Infiuence of neuropeptides on neutrophil adhesion and transmigration through a lung fibroblast barrier in vitro. Exp. Lung Res. 27, 25-46. 

Another important group of molecules facilitating the adhesion and transmigration of lymphocytes is the metalloproteinases (MMPs), a family of... 

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