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Chemokine angiogenic activity

Addison CL, Daniel TO, Burdick MD, et al. The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. J Immunol 2000 165 5269-5277. [Pg.86]

The CXC Chemokines That Display Disparate Angiogenic Activity... [Pg.320]

The progression and growth of ovarian carcinoma are also dependent on chemokine-mediated angiogenesis. In one study, the in vitro production of CXCL8 by five human ovarian cancer lines correlated with tumor neovascularization and cancer-related death when implanted into the peritoneum of immunocompromised mice, whereas VEGF production correlated only with ascites production after implantation, but basic FGF did not correlate with the outcome [70]. This concept was further substantiated in patients with ovarian cancer where ascites fluid angiogenic activity directly correlated to CXCL8 [71]. [Pg.137]

Keane MP, Arenberg DA, L5uich JP, et al. The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol 1997 159 1437-1443. [Pg.256]

FigufS 1 Interferon-inducible ELR CXC chemokine I-TAC/CXCLll inhibits the angiogenic activity of IL-8, bFGF, and VEGF. [Pg.304]

Benelli R. Distinct chemotactic and angiogenic activities of peptides derived from Kaposi s sarcoma virus encoded chemokines. Int J Oncol 2000 17(1) 75-81. [Pg.48]

To demonstrate that CXC chemokines display disparate angiogenic activity, endothelial cell chemotaxis was performed in the presence or absence varying concentrations of IL-8, ENA-78, PF4, and IP-10. Both IL-8 and ENA-78 demonstrated a dose-dependent increase in endothelial migration with an EC50 of 5 nM (57). In contrast, neither... [Pg.175]

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See also in sourсe #XX -- [ Pg.716 ]



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Angiogenic

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