Chemoembolization randomized trials

Chemoembolization Randomized Trials Three randomized studies of groups of patients (Madden et al. 1993 Groupe d Etude et de Traitement du Carcinome Hepatocellulaire 1995 Pelletier et al. 1991), summarized in the French and American literature, with unresectable HCC without severe... [Pg.193]

Patton TJ Kavanagh JJ (1991) Five-year survival in patients given intra-arterial chemotherapy prior to radiotherapy for advanced squamous carcinoma of the cervix and vagina. Gynecol Oncol 42 54-59 Pelage JP et al. (1999) Arterial anatomy of the female genital tract variations and relevance to transcatheter embolization of the uterus. AJR Am J Roentgenol 172 989-994 Pelletier G et al. (1990) A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma. J Hepatol 11 181 184 Pentecost MJ et al. (1993) Hepatic chemoembolization safety with portal vein thrombosis. J Vase Interv Radiol 4 347 351... [Pg.222]

You and colleagues (2005) evaluated the combination of systemic chemotherapy and chemoembolization. Chemoembolization was performed using a mixture of 10 ml lipiodol, 1500 mg 5-FU and 15 mg leucovorin. Two weeks following chemoembolization, patients underwent systemic chemotherapy with 2600 mg/m 5-FU continuous infusion for 24 h and received 150 mg leucovorin (intravenous bolus). The course of chemotherapy was repeated weekly for 24 weeks. The median disease-free interval was 12 months and the median survival time was 16 months. In conclusion the authors suggested that the results of this study are of sufficient interest to justify future randomized trials (You et al. 2005). [Pg.55]

Agarwala SS, Panikkar R, Kirkwood JM (2004) Phase I/II randomized trial of intrahepatic arterial infusion chemotherapy with cisplatin and chemoembolization with cisplatin and polyvinyl sponge in patients with ocular melanoma metastatic to the liver. Melanoma Res 14 217-222... [Pg.58]

Llovet J, Bruix J (2003) Systematic review of randomized trials for unresectable hepatocellular carcinoma chemoembolization improves survival. Hepatology 37 429-442... [Pg.60]

Patt YZ, Chuang VP, Wallace S, Hersh EM, Freireich EJ, Mavligit GM (1981) The palliative role of hepatic arterial infusion and arterial occlusion in colorectal carcinoma metastatic to the liver. Lancet 1 349-350 Pelletier G, Ducreux M, Gay F et al (1998) Treatment of unresectable hepatocellular carcinoma with lipiodol chemoembolization a multicenter randomized trial. Groupe CHC. J Hepatol 29 129-134... [Pg.60]

Raoul JL, Guyader D, Bretagne JF et al (1997) Prospective randomized trial of chemoembolization versus intra-arterial injection of 1311-labeled-iodized oil in the treatment of hepatocellular carcinoma. Hepatology 26 1156-1161... [Pg.92]

Kawai S et al. (1997) Prospective and randomized trial of lipiodol-transcatheter arterial chemoembolization for treatment of hepatocellular carcinoma a comparison of epirubicin and doxorubicin (second cooperative study). The Cooperative Study Group for Liver Cancer Treatment of Japan. Semin Oncol 24 [Suppl 6] S6-38-S6-45... [Pg.140]

Despite these encouraging preliminary results, there are no reports showing that RF ablation, performed alone or in combination with intra-arterial procedures, results in improved survival in patients with intermediate stage HCC. A randomized trial comparing an optimized RF technology with chemoembolization would be needed to establish the potential role of the technique in this patient population. [Pg.334]

Lo CM, Ngan H, Tso WK, Liu CL, Lam CM, Poon RT, Fan ST, WongJ (2002) Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 35 1164-1171... [Pg.60]

Salman HS, Cynamon J, Jagust M, Bakal C, Rozenblit A, Kaleya R, Negassa A, Wadler S (2002) Randomized phase II trial of embolization therapy versus chemoembolization therapy in previously treated patients with colorectal carcinoma metastatic to the liver. Clin Colorectal Cancer 2 173-179... [Pg.61]

Gamma C, Schepis F, Orlando A, Albanese M, Shahied L, Trevisani F, Andreone P, Craxi A, Cottone M (2002) Transarterial chemoembolization for unresectable hepatocellular carcinoma meta-analysis of randomized controlled trials. Radiology 224 47-54... [Pg.120]

Trevisani F, De Notariis S, Rossi C, Bernard M (2001) Randomized control trials on chemoembolization for hepatocellular carcinoma is there room for new studies J Clin Gastroenterol 32 383-389... [Pg.121]

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