Chemistry, protein phosphorylation

Glycogen phosphorylase was the first enzyme shown to be regulated via protein phosphorylation (Krebs, 1959). In recognition of their trad-blazing work, Edwin Krebs and Edmond Fisher were rewarded the Nobel prize for Chemistry in 1992. 

Bridges, A. (1995) The emerging role of protein phosphorylation and cell cycle control in tumor progression. Chemtracts Organic Chemistry 8, 73-107. 

Some believe that in mammalian systems, nearly every protein has an interesting feature of primary structure associated with it. Thus, considerable research attention is focused on PTMs, with recent software developed to provide some characterization [77]. For analysis of the phosphoproteome, the Chait [78], Smith [79], and Aebersold [80] laboratories have published targeted approaches that use the specific chemistry of phosphorylated... 

Constitutive phosphorylation of the acidic tails of the high mobility group 1 proteins by casein kinase II alters their conformation, stability, and DNA binding specificity. The Journal of Biological Chemistry, 27A, 20116-20122. 

Kulkarni, G., Rao, G.S., Srinivasan, N.G., Hofer, H.W., Yuan, P.M. and Harris, B.G. (1987) Ascaris suum phosphofructokinase. Phosphorylation by protein kinase and sequence of the phosphopeptide. Journal of Biological Chemistry 262, 32-34. 

Seibert, M. A., Anderson, K. A., Huang, Q., Goldstein, E. G., Means, A. R. and Edelman, A. M., 1995, Phosphorylation and activation of Ca2+ -calmodulin-dependent protein kinase IV by Ca2+ -calmodulin-dependent protein kinase la kinase Phosphorylation of threonine 196 is essential for activation, The Journal of Biological Chemistry, 270, pp 17616-17621. 

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