Chemical Inspection and Testing Institute

Citi, Chemicals Inspection and Testing Institute, eds.. Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCE Chemical... 

Hino, Y, K.Yamasaki, and K.Schiraishi. 1992. Twenty-eight-day repeated inhalation toxicity study of HCFC 141b in rats. Report B 18-0005, Hita Research Laboratory Chemical Biotesting Center, Chemicals Inspection and Testing Institute, Japan. 

Chemical Inspection and Testing Institute of Japan Report on Advanced Refining Technologies for Gas Oil Distillate (1989). 

The main compounds of the flame retardant Bromcal 70-5 DE contained tetrabromodiphenylether (41%) and 2 pentabromodiphenylethers (45% and 7%) as was found by Sundstrom and Hutzinger [263]. However, the Chemische Fabrik Kalk GmbH, Germany, stopped the production in 1985 Water solubility 0.9 ng 1 [259]. The BGF value was determined by the Chemical Inspection and Testing Institute, Tokyo. However, this BCF value is too low, because after 8 weeks no steady-state is reached and because the concentration in the water was 10 pg l b That is more than 10,000 times higher than the water solubility. 

There is only little information available on bioconcentration using PBDEs in fish and other aquatic organisms. In 1982 the Chemicals Inspection and Testing Institute in Tokyo, Japan, investigated the bio concentration of pentabromobi-phenyl ether in carp [259,293]. The fish were exposed for 8 weeks to commercial pentabromobiphenyl ether at a concentration of 10 and 100 pg 1 The bioconcentration factors (on a wet wt. basis) were more than 10,000. However, it is clear that for such super-hydrophobic chemicals with log values of 6.64 - 6.97 no steady-state is reached after 8 weeks. The second reason that this BCF value was underestimated is that the test chemicals concentration in the water was ca. four to five orders of magnitude higher than the water solubility. The water solubility of pentabromobiphenyl ether (PBDE) is 9 X 10 mg 1 = 0.9 ng 1-1 at20°C [259]. 

Chemicals Inspection and Testing Institute Japan (1992) Data of existing chemicals based on the CSCL Japan. Japan Chemicals Industry Ecology-Toxicology 8c Information Center... 

Chemicals Inspection and Testing Institute (Ed.), compiled under the supervision of the Ministry of International Trade and Industry, Japan, Biodegradation and Bioaccumulation data of Existing Chemicals based on CSCL, Japan, JETOC, Tokyo, 1992, pp. 493. 

Column A 30 X 4.6 L-column (porous silica gel with internal surfaces coated with octadecyl groups and external surfaces coated with glycerylpropyl groups) (Chemical Inspection and Testing Institute, Tolqro) B 250 X 4.6 Sumichiral OA-2500S ((R)-N-(3,5-dinitrobenzoyl)-... 

Column 250 X 4.6 5 p,m L-Column ODS (Chemicals Inspection and Testing Institute, Tokyo)... 

In 1992, the Center for Chemical Process Safety (CCPS), a section of the American Institute of Chemical Engineers, released a how-to book [28] which contains practical appendices on inspection and test procedures. These appendices comprise the practices at major chemical manufacturing facilities. Chapter 8 should be consulted for specific information and actual plant programs. 

In Tables 6.3 and 6.4 RMs of three major producers are mentioned, i.e. the World Health Organization (WHO, International Standards), BCR (European Union, CRMs) and the National Institute of Standards and Technology (NIST, USA, SRMs). Some important national producers of clinical reference materials are the Chemicals and Inspection Testing Institute (CITI, Japan), National Institute for Biological Standards and Control (NIBSC, UK), and Deutsche Gesellschaft fiir Klinische Chemie (DGKC). There are numerous commercial producers of secondary reference materials. 

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