Drug discovery chemical genetics

Capitalizing on self-assembly and nanoscience will enhance the ability to screen drugs for individual sensitivities. Advances in drug discovery, combinatorial synthesis, and screening with sensors that have the ability to detect multitudes of specific genetic matches—marrying microelectronics and self-assembly—are expected to be near-term breakthroughs. Then the creation of advanced forms of in the field or in the office tests for chemical risks, pharmaceutical compatibility, or environmental hazards will be possible. 

Effective P13K/PKB pathway interruption has also been reported with a series of compoimds whose mechanism of action is still unknown. The three examples reviewed in this section also illustrate the potential application and challenges that chemical genetics may face in this area of drug discovery. 

Animal models of disease play a critical role in the drug discovery process and are important in the lead candidate selection process as well. Categories of animal disease models include spontaneous disease, induced models (e.g., chemically, immunologically), xenograft models, infection models, and genetically modified models (e.g., transgenic knockouts (KOs) or knock-ins (KIs), humanized animals (e.g., expressing the human protein or receptor). The sub-... 

The Value of Chemical Genetics in Drug Discovery Table 3.1 Natural products used to identify targets. 

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