Chemical agents imprinted polymers

Nieuwenhuizen and Harteveld [92] have realized a nerve agent dosimeter gas sensor based on the strong interaction between certain metal ions and organophosphorus compounds. In this case, the sensor material contains La(III) 2-bis(carboxymethyl)amino hexadecanoic acid and different factors such as humidity, concentration and layer thickness have been studied and optimized. Using a combination of a metallic complex with a molecular-imprinted polymer, a very sensitive sensor was developed for the detection of soman, a chemical warfare agent (the detection limit was 7 ppt) [93]. The biosensing material is based on a polymer coated onto a fiber-optic probe modified with a luminescent europium detection complex. This complex was... 

Boyd, J.W., Cobb, G.P, Southard, G.E., and Murray, G.M., 2004. Development of molecularly imprinted polymer sensors for chemical warfare agents, Johns Hopkins APL Tech. Digest, 25. pp. 44-49. 

MIPs can be synthesized in the pores and on the surface of pre-made porous particles. Porous silica particles have been applied for this purpose. To ensure that the imprinted polymer is attached firmly to the particle, the particles are often chemically modified by coupling of polymerizable groups or initiator molecules to the particle surface prior to the MIP polymerization [100-102]. The use of immobilized initiators is often referred to as the iniferter (initiator-transfer agent-terminator) approach [103]. The method has been applied to the imprinting of a range of templates [104—107]. 

Zhou Y, Yu B, Shiu E, Levon K (2004) Potentiometric sensing of chemical warfare agents surface imprinted polymer integrated with an indium tin oxide electrode. Anal Chem 76(10) 2689-2693... 

Molecularly Imprinted Polymers for the Detection of Chemical Agents in Water... 

New sensors have also been developed for chemical nerve agents and nerve agent analogues or simulators. The detection of a nerve agent analogue, pinacolyl methylphosphonate (PMP), has been demonstrated using an electrochemically, molecularly-imprinted polymer (MIP) polythiophene film set on a quartz crystal microbalance (QCM) transducer surface. " A nerve gas sensor for dimethyl methylphosphonate (DMMP) has also been based on chemically (p-phenylenediamine)-reduced graphene... 

Pavel, D. Lagowski, J. Lepage, C. J., Computationally designed monomers for molecular imprinting of chemical warfare agents e Part V, Polymer. 2006, 47, 8389-8399... 

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