Cervical incompetence

Because of its use in the treatment of female infertility, which inevitably involves early exposure of some embryos, the safety of bromocriptine in early pregnancy has been systematically evaluated in a large multicenter study with prolonged follow-up (SEDA-13, 112). There was no evidence that this use of bromocriptine was associated with an increased risk of spontaneous abortion, multiple pregnancy, or the occurrence of congenital malformations nor did exposure in utero seem to have any adverse effects on postnatal development. Cervical incompetence may be a problem at the time of delivery, but this may well be due to a long history of infertility rather than to the drug itself. 

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