Cerebral cortex regions

Figure 21.2 Mass spectra obtained from the cerebral cortex region (a) of mouse brain. Signals with good S/N ratios were obtained from thin slices. Modifed with permission from Sugiura et al.3...

Lewis DA, Melchitzky DS, Sesack SR, Whitehead RE, Auh S, Sampson A (2001) Dopamine transporter immunoreactivity in monkey cerebral cortex regional, laminar, and ultrastructural localization. J Comp Neurol 432 119-136. 

Abbas N, Bednar I, Mix E, Marie S, Paterson D, Ljungberg A, Monis C, Winblad B, Nordberg A, Zhu J (2002) Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-iegulahon of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice. J Neuroimmunol 126 50—57. 

Figure 12.12. Lipid profile of the cerebral cortex region with MALDI-MS. (Reproduced from ref. 36 by permission of Elsevier, copyright 2005 American Society for Mass Spectrometry.)...

FIGURE 3.30 Mass spectra obtained from the cerebral cortex region [66]. The mass spectra obtained from the cerebral cortex region in mouse brain slices (a white circle in (A) with thicknesses of 2 0.m (B), 5 pm (C), 10 pm (D), 15 pm (E), 30 pm (F), and 40 pm (G). A larger number of mass peaks with high signal-to-noise (S/N) ratios were observed in the spectra obtained from sections with 2, 5, and 10 pm thicknesses than in those obtained from sections with 15, 30 and 40 pm thicknesses. 

Autoradiography and receptor mRNA studies have shown Hi receptors to be located in most of the brain areas innervated by the ascending histaminergic axons, e.g. cerebral cortex, hippocampus, limbic areas and hypothalamus. Their presence in the cerebellum is not accompanied by appropriate histaminergic innervation. Very few are found in the striatum but this region does show a high density of H2 receptors. H2 receptors are also found with Hi in the cortex, hippocampus and limbic areas, but not in the hypothalamus. Although basically presynaptic the H3 receptor is also found postsynaptically in the striatum and cerebral cortex (Pollard et al. 1993). 

Blue, M.E. Kosofsky, B.E. and Molliver, M.E. Regional differences in the serotonin innervation of rodent cerebral cortex Differential distribution of two morphologically distinct axon types. Abstr Soc Neurosci 14 209,... 

The pathologic hallmarks of the disease in the brain include neurofibrillary tangles and neuritic plaques made up of various proteins, which result in a shortage of the neurotransmitter acetylcholine. These are primarily located in brain regions involved in learning, memory, and emotional behaviors such as the cerebral cortex, hippocampus, basal forebrain, and amygdala.11... 

The cell bodies of third-order sensory neurons are located in the thalamus. These neurons transmit the pain signal to the somatosensory cortex. The function of this region of the brain is to localize and perceive the intensity of the painful stimulus. Further transmission of the signal to the association areas of the cerebral cortex is important for the perception and meaningfulness of the painful stimulus. 

---