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Cerebral cortex lead damage

Such imbalanced antioxidant systems in schizophrenia could lead to oxidative stress- and ROS-mediated injury as supported by increased lipid peroxidation products and reduced membrane polyunsaturated fatty acids (PUFAs). Decrease in membrane phospholipids in blood cells of psychotic patients (Keshavan et al., 1993 Reddy et al., 2004) and fibroblasts from drug-naive patients (Mahadik et al., 1994) as well as in postmortem brains (Horrobin et al., 1991) have indeed been reported. It has also been suggested that peripheral membrane anomalies correlate with abnormal central phospholipid metabolism in first-episode and chronic schizophrenia patients (Pettegrewet al., 1991 Yao et al., 2002). Recently, a microarray and proteomic study on postmortem brain showed anomalies of mitochondrial function and oxidative stress pathways in schizophrenia (Prabakaran et al., 2004). Mitochondrial dysfunction in schizophrenia has also been observed by Ben-Shachar (2002) and Altar et al. (2005). As main ROS producers, mitochondria are particularly susceptible to oxidative damage. Thus, a deficit in glutathione (GSH) or immobilization stress induce greater increase in lipid peroxidation and protein oxidation in mitochondrial rather than in cytosolic fractions of cerebral cortex (Liu et al., 1996). [Pg.289]

Nervous System. Structural and functional nervous system effects of lead are apparent. These effects involve the brain, cerebellum, spinal cord, and motor and sensory nerves leading to specific areas of the body. Neural tissue is very sensitive to the toxic effects of lead with cases of brain swelling reported at even low lead concentrations. Severe subcellular damage is usually noted in the cerebellar cortex and cerebral cortex, and sometimes in the basal ganglia. This damage also impairs the flow of blood in the brain [25]. [Pg.22]


See other pages where Cerebral cortex lead damage is mentioned: [Pg.78]    [Pg.183]    [Pg.75]    [Pg.310]    [Pg.201]    [Pg.109]    [Pg.1709]    [Pg.635]    [Pg.132]    [Pg.66]    [Pg.58]    [Pg.221]    [Pg.177]    [Pg.252]    [Pg.142]    [Pg.556]    [Pg.49]    [Pg.628]    [Pg.22]    [Pg.53]   
See also in sourсe #XX -- [ Pg.75 , Pg.114 , Pg.117 ]




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