Cerebral cortex compounds

The collaboration between several academic laboratories has shown that the imidazole moiety on some of the earlier H3 antagonists can be replaced with a piperidine. For example, the ciproxifan analogue (16) has a pK of 8.4 in rat cerebral cortex [80]. This compound showed in vivo efficacy after p.o. administration to a mouse. Other piperidines studied by these researchers include (17) (H3 p 2 = 7.21 in guinea-pig ileum) [81] and (18) (human K[ — 2.8 nM, p 2 = 7.42 in guinea-pig ileum) [82]. The authors have also found that benzyl ethers such as (19) are somewhat weaker H3 antagonists (p 2 = 6.3 in guinea-pig ileum) [83]. 

On the other hand, the results using the hippocampal seizure model revealed an interesting profile of anticonvulsant effects for PCP and ketamine, compared to several classical anticonvulsant compounds. When tested against the unkindled hippocampal seizure, the effects of behaviorally equivalent doses of PCP and ketamine were remarkably similar, but differed substantially from the effects of the anticonvulsant drugs. The compression of the entire EEG seizure episode to a shorter duration was unique to PCP and ketamine, and suggests an anticonvulsant effect. Conversely, the small prolongation of the initial AD episode, and the decreased duration of the postictal depression, could be reflective of pro-convulsive influences. There were, however, no other indications of enhanced seizure activity, such as the appearance of motor convulsions or spread of seizure activity to the cerebral cortex. 

If a pregnant woman is affected by mercury poisoning, the consequences may affect the child. As a result, the child may suffer from profound mental deficiency, atrophy of cerebral cortex, commisure and cerebellum neuron destruction. Acrodynia is a syndrome that affects children exposed to organic and inorganic mercury compounds. Symptoms include itchy, measles-like rash followed by desquamation of palm and foot skin, essential tachycardia, generalized swellings, hypertension and salivation (Harada, 1995). 

PAM I seems to be less effective than IV In reactivating brain cholinesterase after its inactivation by paraoxon or other OP compounds.There was early evidence that 2-PAM I produced more reactivation of cholinesterase in the pontomedullary region and the area postrema that had been inhibited by paraoxon than in the cerebellum and the cerebral cortex TO and that it could prevent the appearance of grand mal-llke discharges in EEGs of rabbits after doses of sarin that evoked such discharges in rabbits not protected... 

T3. Terezinha de Souza Wyse, A., Serra Bavaresco, C., Elisabeth Kienzle Hagen, M., Delwing, D., Milton Duval Wannmacher, C., Severo Dutra-Filho, C., and Wajner, M., In vitro stimulation of oxidative stress in cerebral cortex of rats by the guanidino compounds accumulating in hyperargininemia. Brain Res. 923, 50-57 (2001). 

The H2-stimulated adenylate cyclase response is sensitive to inhibition by a range of psychotropic drugs. A large number of neuroleptic drugs are effective inhibitors of histamine-stimulated cyclase activity in rabbit cerebral cortex [158, 192] and guinea-pig hippocampus and cerebral cortex [81, 193]. The most potent compounds in homogenates of guinea-pig hippocampus appear to... 

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