Central nervous system depressants alcohol interacting with other

PCP has a sedative effect on certain systems in the body and interactions with other central nervous system depressants such as alcohol and benzodiazepines may lead to coma or accidental overdose. 

Pharmacodynamic alcohol interactions are also of great clinical significance. Additive central nervous system depression with other sedative-hypnotics is most important. Alcohol also potentiates the pharmacologic effects of many nonsedative drugs, including vasodilators and oral hypoglycemic agents. There is some evidence that alcohol also enhances the antiplatelet action of aspirin. 

Central nervous system depression is multiplied when BZDs are taken with other downers interaction with alcohol can be lethal, even after only a few pills and a couple of drinks. The drugs last for a very long time in the body tis sues, and people may not be aware that even a short-acting sleeping pill such as Halcion can have aftereffects the next day. Longer-acting BZDs can last for several days. 

Although workers are often exposed to a variety of solvents with Stoddard solvent, there are no available studies specifically characterizing the interactions of Stoddard solvent with other chemicals. Since Stoddard solvent may have adverse effects on the nervous system, it may compound the effects of other chemicals that cause central nervous system depression, such as alcohol, barbiturates, benzodiazepines, or medical anesthetics. Guinea pigs with a diet high in vitamin C survived a high exposure to Stoddard solvent vapors better than those with a diet low in vitamin C (Jenkins et al. 1971) however, it is not known how vitamin C levels might affect humans exposed to Stoddard solvent. 

Drug interactions morphine has additive effects when used in conjunction with alcohol, other opioids, or illicit drugs that cause central nervous system depression because respiratory depression, hypotension, and profound sedation or coma may result. 

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