Cellular signaling receptors

B. Goldstein, Kinetic proofreading in receptor-mediated transduction of cellular signals receptor aggregation, partially activated receptors, and cytosolic messengers, Bull. Math. Biol. 2002, 64, 887-911. 

Cato AC, Nestl A, Mink S (2002) Rapid actions of steroid receptors in cellular signaling pathways. Sci STKE 2002 RE9. 

Lanzafame A A, Christopoulos A, Mitchelson F (2003) Cellular signaling mechanisms for muscarinic acetylcholine receptors. Recept Chann 9 241-260... 

Many environmental toxins interact with specific cellular receptors, including enzymes, ion channels and ion pumps, and thus provide natural tools for the study of cellular signalling pathways. Palytoxin, a compound isolated from the coelen-terate of genus Palythoa, is one such useful and intriguing compound. The structure of palytoxin was first determined in 1981 independently by Hirata (7) and Moore (2). As one of the most potent marine toxins known, palytoxin has been studied in a variety of systems ranging from erythrocytes to neurons. As a tumor promoter of the non 12-O-tetradecanoylphorbol-13-acetate (TPA) type, palytoxin can also be studied in the context of a growth control system. 

MacEwan, D. 2002. TNF receptor subtype signalling differences and cellular consequences. Cellular Signalling 14(6), 477-492. 

At least five distinct muscarinic receptor genes have been cloned and sequenced. The genes are called Wj to m5. They correlate with the M to M5 receptors identified pharmacologically. The subtypes differ in their ability to couple to different G proteins and, hence, to elicit cellular signaling events. 

G protein-coupled receptor interacting proteins emerging roles in localization and signal transduction. Cellular Signalling, 14, 297-309. 

Deoxycholic acid has also been demonstrated to activate other pivotal oncogenic pathways in CRC cells in vitro including p-catenin/T-cell factor-mediated transcription, extra-cellular signal-regulated kinase activation downstream of the epidermal growth factor receptor and Jun-N-terminal kinase... 

Considerable evidence supports the involvement of protein kinase C (PKC) in both the early and delayed preconditioning (Baines et al. 2001 Liu et al. 1994). PKC-8 is activated by diacylglycerol while it is unresponsive to Ca2+ (Kent et al. 1996). PKC-8 has been shown to have an essential role in the cellular signaling cascade that leads to the delayed protective effect of A3 receptor stimulation in the mouse heart (Zhao and Kukreja 2003). 

Yoshino, T.P., Boyle, J.P. and Humphries, J.E. (2001) Receptor-ligand interactions and cellular signalling at the host-parasite interface. Parasitology 123, SI 43—SI 57. 

---