Cellular Gene Expression in Adenovirus-Infected Cells

Induction of Cellular Gene Expression in Adenovirus-Infected Cells 

We have seen that adenovirus infection of quiescent human or rodent cells induces the synthesis of such enzymes as thymidine kin- 

We have seen that the properties and location of the H5hrl mutation implicate the products of the ElA-a mRNA (see Fig. 2A) in 

The relevance of the examples of activated cellular gene expression that have been reported so far to the life cycle of the virus has also to be established. Adenovirus depends on its hose cell for a large number of products, whose synthesis might be expected to be enhanced soon after infection to prime the cell for the period when massive quantities of viral DNA, late mRNA, and structural proteins are made. At this juncture, it is, however, difficult to appreciate the significance of increased expression of such genes as those encoding P-tubulin and the 70K heat-shock protein. This may reflect our ignorance about many aspects of the virus-cell interaction. Alterna- 

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