Cells, differentiation regulation

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Lee GR, Kim ST, Spilianakis CG, Fields PE, Flavell RA T helper cell differentiation regulation by cis elements and epigenetics. Immunity 2006 24 369-79. 

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ZHU J, PAUL WE (2010b), Peripheral CD4-I- T-cell differentiation regulated by networks of cytokines and transcription factors , Immunol Rev, 238,247-62. 

PAMPs and various tissue factors can prime DCs to produce T-cell-polarizing factors [21], IL-12 is a pro-inflammatory cytokine that induces IFN-y and promotes the development of Thl-cell differentiation [31], Other Thl-polarizing factors are IFN-a and IFN-(3 [32] and cell-surface expressed intracellular adhesion molecule (ICAM)-l [33]. On the other hand, it has been shown that NF-kB inducing kinase (NIK), which is known to regulate B-cell maturation and lymphoid organogenesis, is important for the induction of Thl7 cells [34],... 

Ray P. Krishnamoorthy N. Ray A Emerging functions of c-kit and its ligand stem cell factor in dendritic cells regulators of T cell differentiation. Cell Cycle 2008 7 2826-2832. 

Figure 37-14. Alternative promoter use in the liver and pancreatic B cell glucokinase genes. Differential regulation of the glucokinase GK) gene is accomplished by the use of tissue-specific promoters. The B cell GK gene promoter and exon 1B are located about 30 kbp upstream from the liver promoter and exon 1L. Each promoter has a unique structure and is regulated differently. Exons 2-10 are identical in the two genes, and the GK proteins encoded by the liver and B cell mRNAs have identical kinetic properties.

A Retinol, p-carotene Visual pigments in the retina regulation of gene expression and cell differentiation p-carotene is an antioxidant Night blindness, xerophthalmia keratinization of skin... 

A most important function of vitamin A is in the control of cell differentiation and mrnover. PsA-trans-retinoic acid and 9-cw-retinoic acid (Figure 45-1) regulate growth, development, and tissue differentiation they have different actions in different tissues. Like the steroid hormones and vitamin D, retinoic acid binds to nuclear receptors that bind to response elements of DNA and regulate the transcription of specific genes. There are two families of nuclear retinoid receptors the retinoic acid receptors (RARs) bind all-rrijw-retinoic acid or 9-c -retinoic acid, and the retinoid X receptors (RXRs) bind 9-cw-retinoic acid. 

Luther SA, Cyster IG (2001) Chemokines as regulators of T cell differentiation. Nat Immunol 2 102-107... 

Sozzani S, Allavena P, D Amico G, et al. Differential regulation of chemokine receptors during dendritic cell maturation a model for their trafficking properties. J Immunol 1998 161 1083-1086. 

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