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Cell adhesion, protein-mediated biomaterials

Cell adhesion, protein-mediated, on biomaterials, 143-145 Ceramics... [Pg.207]

Inside the human body, cell adhesion to foreign biomaterial surfaces is mediated by a layer of proteins found in the blood or serum. Biomaterials that are able to control the adsorption of blood proteins will be able to control selectively the adhesion of cells. This function underlies the so-called biocompatibility of... [Pg.1099]

Fig. 8. Schematic representation of protein-mediated cell adhesion on biomaterial surfaces. Biomaterial surface properties (such as hydrophilicity/hydrophobicity, topography, energy, and charge) affect subsequent interactions of adsorbed proteins these interactions include but are not limited to adsorbed protein type, concentration, and conformation. Changes in protein-surface interactions may alter accessibility of adhesive domains (such as the peptide sequence arginine-glycine-aspartic acid) to cells (such as osteoblasts, fibroblasts, or endothelial cells) and thus modulate cellular adhesion. (Adapted and redrawn from Schakenraad, 1996.)... Fig. 8. Schematic representation of protein-mediated cell adhesion on biomaterial surfaces. Biomaterial surface properties (such as hydrophilicity/hydrophobicity, topography, energy, and charge) affect subsequent interactions of adsorbed proteins these interactions include but are not limited to adsorbed protein type, concentration, and conformation. Changes in protein-surface interactions may alter accessibility of adhesive domains (such as the peptide sequence arginine-glycine-aspartic acid) to cells (such as osteoblasts, fibroblasts, or endothelial cells) and thus modulate cellular adhesion. (Adapted and redrawn from Schakenraad, 1996.)...
C. Protein-Mediated Cell Adhesion on Biomaterial Surfaces... [Pg.143]

Endothelial cells, protein-mediated cell adhesion on biomaterials, 143... [Pg.208]

Cell adhesion takes place in two different stages. The first stage consists of the adsorption of a layer of proteins that selectively adhere onto the biomaterial surface, and is completed in an interval from seconds up to a few minutes [40]. This is mainly mediated by the surface properties. The second stage involves cell adhesion onto the layer of proteins. This is a more complex process, mediated by extracellular matrix (ECM) proteins, cell mem-... [Pg.220]

Fibronectin is one of the main protein components of the extracellular matrix and is known to mediate the phenomena of surface adhesion in eukaryotic cells. This protein plays an important role in infections associated with biomaterials and it has been shown that S. aureus has specific receptors for this protein. Similarly, fibrinogen promotes adherence of bacteria, especially staphylococci to biomaterials. ... [Pg.360]

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See also in sourсe #XX -- [ Pg.143 , Pg.144 ]



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Cell adhesion

Cell adhesion proteins

Cell adhesion, protein-mediated

Cell adhesive

Cell mediated

Cell-adhesive proteins

Protein adhesion

Protein-Mediated Cell Adhesion on Biomaterial Surfaces

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