Celiprolol

Alkylation of tcrt-butylamine (46) with 45 affords celiprolol (47) [10]. 

Endomethylene-A -tetrahydro benzaldehyde Cyclothiazide Epibromohydrin Carteolol Epichlorohydrin Acebutolol Atenolol Befunolol Betaxolol HCI Bufetrol Bunitrolol Bupranolol Carazolol Carnitine Celiprolol Colestipol Cromolyn sodium I ndenolol Mazindol Mepindolol Metoprolol tartrate Nadolol Nifuratel Oxprenolol Penbutolol Practolol Propafenone HCI Propranolol HCI Viloxazine HCI Xanthinol niacinate Epinephrine... 

J., Artursson, P., Transport of celiprolol across human intestinal epithelial (Caco-2) cells mediation of secretion by multiple transporters including P-glycoprotein, Br. J. Pharmacol. 1993, 3 30, 1009-1016. 

Lipka E, Spahn-Langguth S, Mutschler E and Amidon GL (1998) In Vivo Non-Linear Intestinal Permeability of Celiprolol and Propranolol in Conscious Dogs Evidence for Intestinal Secretion. EurJ Pharm Sci 6 pp 75-81. 

Fig. 3.10 Structures of pafenolol and celiprolol, derivatives of the talinolol (see Figure 3.6) structure which show similar bioavailability characteristics.

The simultaneous identification and quantification in human plasma of 14 BB (atenolol, sotalol, diacetolol, carteolol, nadolol, pindolol, acebutolol, metoprolol, celiprolol, oxprenolol, labetalol, propranolol, tertatolol, and betaxolol) was achieved by Delamoye et al. [78] using LLE, RPLC C18 (250mmx4.6mmx5pm) separation using a gradient of acetonitrile-phosphate buffer pH 3.8 at a... 

More hydrophilic /3-blockers, such as atenolol, bisoprolol, celiprolol, pindolol and sotalol are predominantly eliminated via the kidney. In elderly patients this may require adaptation of the dosage. Most of the shorter acting /3-blockers are available as slow release preparations. Accordingly, when used as antihypertensives /3-blockers are usually administered once daily. For other applications such as angina pectoris a twice daily dosage may be required. 

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