Probenecid Cefuroxime

Garton AM, Rennie RP, Gilpin J, et al. Comparison of dose doubling with probenecid for sustaining serum cefuroxime levels. J Antimicrob Chemother 1997 40 903-906. 

A reversed-phase HPLC post-column ion-pair extraction system was developed by Kim and Stewart [71, 72] for the analysis of carboxylic acid drugs and their salts (sodium formate, sodium acetate, 3-bromopropionic acid, 6-aminocaproic acid, 11-bromoundecanoic acid, 1-heptanesulfonic acid, / -n i t rophcny 1 acetic acid, sodium benzoate, sodium salicylate, valproic acid, probenecid, naproxen, ketoprofen, ibuprofen, mefenamic acid, flufenamic acid, and cefuroxime sodium) using a-(3,4-dimethoxy-phenyl)-4,-trimethylammoniummethylcinnamonitrile methosulfate... 

Ceftriaxone 250 mg IM once or ciprofloxacin 500 mg p.o. once or norfloxacin 800 mg p.o. or cefuroxime axetil 1 g p.o. once plus probenecid 1 g or cefotaxime 1 g IM once or ceftizoxime 500 mg IM once plus Doxycycline 100 mg two times daily for 7 days or tetracycline 500 mg four times daily for 7 days... 

---