Cefoperazone analysis

C. M. Selavka, I. S. Krull, and K. Bratin, Analysis for penicillins and cefoperazone by HPLC-photolysis-electrochemical detection (HPLC-hv-EC), J. Pharm. Biomed. Anal., 4 83 (1986). 

Parker, C.E. Perkins, J.R. Tomer, K.B. Shida, Y. O Heu-a, K. Nanoscale packed capillary liquid chromatography-electrospray ionization mass spectrometry analysis of penicillins and cephems. J.Chromatogr., 1993, 616, 45-57 [capillary HPLC electrospray LC-MS serum also ampiciUin, car-benicUlin, cefalothin, cefazoUn, cefmenoxime, cefmetetzole, cefoperazone, cefotaxime, cefotiam, cefoxitin, cephalexin, cloxacillin, dicloxacillin, peniciUin G, pipericillin, sulbenicillin]... 

Oliveira and Cass described a method for the analysis of cephalosporin antibiotics in bovine milk using RAM columns for on-line sample clean-up. The system was composed of a RAM bovine serum albumin (BSA) phenyl column coupled to a C18 analytical column. Milk samples were directly injected after addition of 0.8 mM solution of tetrabutylammonium phosphate. The standard curve was linear over the range 0.100-2.50 tig/ml for five cephalosporin antibiotics (cefoperazone, cephacetril, cephalexin, cephapirin, and ceftiofur). The limits of quantification and detection reported were 0.100 and 0.050 ttg/ml, respectively. The method showed high intermediate precision [coefficient of variation percent (CV%) 2.37-2.63] and recovery (CV% 90.7-94.3) with adequate sensitivity for drug monitoring in bovine milk samples. 

Using HMDE, the analysis of triamcinolone acetonide (TAA) was performed by square-wave voltammetry (SWV) and a detection limit of 3.0 x 10 mol was attained. The method was successfully applied for the analysis of TAA in tablets and in serum, without pretreatment of the samples. The quantification of haloper-idol was performed under controlled adsorptive accumulation onto HMDE and was applied in low concentrations of the bulk form to pharmaceutical formulatiOTis and human fluids. A limit of quantification (LOQ) of 3.83 x 10 ° mol was calculated by the authors. In another study of the same research group, ethinylestradiol was investigated and a detection limit of 5.9 X 10 ° mol was reported. The analysis of cefoperazone in pharmaceutical formulations and in human plasma was carried by pre-concentration followed by SWV onto an HMDE, attaining a detection limit of 4.5 x 10 ° mol The analysis of the... 

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