Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Intermediate precision

Method precision refers to the variability in measurement of the same sample. There are three main components of method precision repeatability (also known as system or intraassay precision), intermediate precision (also known as inter-assay or intra-laboratory precision), and reproducibility precision (also known as ruggedness, overall or inter-laboratory... [Pg.387]

Intermediate Precision Intermediate precision is defined as the variation within the same laboratory. The extent to which intermediate precision needs to be estab-... [Pg.730]

Precision Intermediate Precision. Sets of six dissolution samples that are prepared using different instruments and by different analysts are used to determine intermediate precision. However, this procedure will not be able to differentiate method variation versus tablet-to-tablet variation. It will predict the worst-case precision that includes tablet-to-tablet, sampling, and analysis variations. [Pg.61]

Intermediate Precision. Intermediate precision expresses within-laboratory variation and is generally performed on different days using different analysts, equipment, and sample preparations. This test may not be applicable if the laboratory has only one workstation. Additionally, this test may not be appropriate for automated workstations that are operating under the same environment and controls within a laboratory. This assumption is made on the basis that the automated workstations are identical (i.e., same configuration, same software and hardware) and that they have been suitably qualified and maintained to a consistent standard and operate under a similar climatic environment. The influence of the analyst is reduced to the preparation of solvents, and this should be covered by the robustness studies. [Pg.76]

Fuel and air or nitrous oxide flow stabilities must be adequate for good precision. Intermediate balast tanks help to smooth out fluctuations caused by compressors.3 As mentioned in Chapter 2, section 5, nitrous oxide cools when it is subjected to a sharp pressure drop, which results in cooling of the cylinder head, and sometimes in instability. The effect is not as important if the nitrous oxide operating pressure... [Pg.51]

The precise intermediates formed in this version of the oxidation are not known, but it is possible that the necessary alkoxysulfonium intermediate is derived from a breakdown of the zwitteiion (15 Scheme... [Pg.296]

S) fi"-D-Galactometasaccharinic Acid.—Kiliani and Sanda reduced their parasaccharinic acid in the usual manner with hydriodic acid and red phosphorus. The product was a hexanoic lactone whose boiling point (217.5°) was precisely intermediate between that (220°) of the n-hexanoic 1,4-lactone obtained by a similar reduction of a -D-galactometasaccharinic acid and that (215°) reported for 2-ethylbutyro-l, 4-lactone. Kiliani, however, chose the latter structure for his lactone, since the corresponding acid, like DL-(2-ethyl-4-hydroxybutyric acid) and unlike either the enantiomor-... [Pg.56]

Animal studies suggest that furan is readily absorbed via all routes of exposure. Furan is oxidized by the cytochrome P450 enzymes in the liver and other tissues and may form epoxide intermediates however, the precise intermediates have not yet been identified. Intermediates of furan may include enedials and dialdehydes, which are metabolized to CO2 and eliminated through the lungs. Examination of urinary output following furan administration in animals revealed a complex mixture of mercapturate metabolites of furan. [Pg.1203]

The precision of an analytical method is the closeness of a series of individual measurements of an analyte when the analytical procedure is applied repeatedly to multiple aliquots of a single homogeneous volume of biological matrix [16], The precision is calculated as coefficient of variation (C.V.), i.e., relative standard deviation (RSD). The measured RSD can be subdivided into three categories repeatability (intra-day precision), intermediate precision (inter-day precision) and reproducibility (between laboratories precision) [16, 78, 79, 81],... [Pg.35]

Intermediate precision. Intermediate precision expresses within-laboratories variations different days, different analysts, different equipment, etc. [13]. The ISO definition used the term M-factor different intermediate precision , where the M-factor expresses how many and which factors (time, calibration, operator, equipment or combinations of those) differ between successive determinations [17]. In a strict sense, intermediate precision is... [Pg.4]

Intermediate precision. Intermediate precision expresses within laboratories variations Different days, different analysts, different equipment, etc. ... [Pg.419]

Intermediate Precision. Intermediate precision expresses the effects of random events on the precision of the analytical procedure within the same lab. The procedure requires repeating the analysis of one technician by a qualified second technician, on a different instrument, using a different lot of HPLC column, on a different day. On the second day of analysis, all reagents and mobile phases are prepared freshly. [Pg.434]

Between-laboratory precision see Interlaboratory precision, Intermediate precision, and Precision). [Pg.368]

Intermediate Precision Intermediate precision expresses the precision under conditions where the results of independent assays are obtained by the same analytical procedure on identical samples in the same laboratory, possibly with different operators and using different instruments, and during a given time interval. This represents the total random error from individual sample results, taking into consideration all the assay variables. [Pg.118]

Method validation for NIR or Raman spectroscopic methods using chemometrics is outlined in USP chapter <1119>. The criteria for method validation are the same as other quantitative analytical methods accuracy, precision, intermediate precision, linearity, specificity, robustness. However, because these methods are statistical in nature and are based on a previously validated analytical method, the validation of MVA methods is somewhat different than traditional analytical methods. [Pg.236]

Intermediate precision Intermediate precision expresses the effects of random events on the precision of the analytical procedure within the same laboratory. The investigation typically includes the analysis of three sample... [Pg.448]

Intermediate Precision—Intermediate precision has been determined as shown in Table 2. [Pg.1061]


See other pages where Intermediate precision is mentioned: [Pg.238]    [Pg.366]    [Pg.19]    [Pg.238]    [Pg.285]    [Pg.460]    [Pg.571]    [Pg.19]    [Pg.571]    [Pg.342]    [Pg.51]    [Pg.8]   
See also in sourсe #XX -- [ Pg.58 , Pg.80 ]

See also in sourсe #XX -- [ Pg.238 ]

See also in sourсe #XX -- [ Pg.25 , Pg.376 ]

See also in sourсe #XX -- [ Pg.237 ]

See also in sourсe #XX -- [ Pg.60 , Pg.61 , Pg.62 ]




SEARCH



Intermediate measurement precision

Intermediate precision analytical method

Intermediate precision condition

Intermediate precision condition measurement

Intermediate precision defined

Intermediate precision test

Intermediate precision, definition

Intermediate precision, statistical validation

© 2024 chempedia.info