Caution in application

Especially at low temperatures, the thermal conductivity can often be markedly reduced by even small traces of impurities. This table, for the highest-purity specimens available, should thus be used with caution in applications with commercial materials. From Perry, EngineeringManual, 3d ed., McGraw-Hill, New York, 1976. A more detailed table appears as Section 5.5.6 in the Heat Exchanger Design Handbook, Hemisphere Pub. Corp., Washington, DC, 1983. f Parallel to basal plane, t Perpendicular to basal plane. 

Thus, there seems to be reason for caution in application of simple resonance or FMO predictions to 2-substituted dienes. We say more about this Topic 10.1. 

While polar monomers are usually beneficial in acrylic PSA formulations, there are times when their presence is deleterious. Examples of this may be the use of acrylic acid containing adhesives for electronic applications, for adhering to some metallic surfaces, or for application to paper used in books. Higher levels of acrylic acid not only increase the acidity of the PSA but they also increase the moisture uptake in the adhesive making dissociation of the acid easier. This can increase corrosion problems in the electronic or metal applications, or severe discoloration and degradation of paper with time. The latter is often a significant concern to librarians who deal with repair and archival restoration of books. In applications such as these, acid-free adhesives are more desirable, or at the very least the amount of acid has to be low and caution has to be taken to fully incorporate the monomer into the PSA. 

The earliest tables were compiled from data collected from nuclear weapon tests, in which very high yield devices produced sharp-peaked shock waves with long durations for the positive phase. However, these data are used for other types of blast waves as well. Caution should be exercised in application of these simple criteria to buildings or structures, especially for vapor cloud explosions, which can produce blast waves with totally different shapes. Application of criteria from nuclear tests can, in many cases, result in overestimation of structural damage. 

Many of the modern, high-performance coatings require a high degree of skill in application and are considerably less tolerant than older, conventional materials. Caution is required in choosing coatings when there is no record of sound work by contractors. 

Application of topical salicylates can lead to systemic effects, especially if the product is applied liberally. Repeated application and occlusion with a wrap or bandage also can increase systemic concentrations.41 Salicylate-containing counterirritants should be used with caution in patients in whom systemic salicylates are contraindicated, such as patients with severe asthma or aspirin allergy.42 Topical salicylates have been reported to increase prothrombin time in patients on warfarin and should be used with caution in patients on oral anticoagulants.43... 

In application of this method to solubility data (8) in the KCl-KBr- O system at 25°C, it is found that equilibrium is in general not attained, though some mid-range compositions may be near equilibrium. As the highly soluble salts are expected to reach equilibrium most easily, considerable caution should be exercised before reaching the conclusion that equilibrium is established in other low-temperature solid solution-aqueous solution systems. It is not appropriate to derive thermodynamic properties of solid solutions from experimental distribution coefficients unless it can be demonstrated that equilibrium has been attained. 

NDGA also inhibits 5-LO in a variety of systems [65-68]. In vivo, antiinflammatory activity has been reported in lipopolysaccharide (LPS)-in-duced knee inflammation in rats [69] and in AAE and croton oil induced ear oedema [70,71]. However, in a 14-day clinical trial in psoriasis, no efficacy was seen following topical application of NDGA [72]. Although this compound has been used as an archetypal 5-LO inhibitor in many studies, the general antioxidant properties of this compound require caution in these interpretations. 

Irritation Tretinoin may induce severe local erythema, pruritus, burning, stinging, and peeling at the application site. If the degree of local irritation warrants, use medication less frequently or discontinue use temporarily or completely. Tretinoin may cause severe irritation to eczematous skin use with caution in patients with this condition. 

At present, the occurrence of stepwise adsorption in the low pressure region is the best criterion for caution in the application of the B.E.T. method. Since it is highly probable that less distinct steps or even several steps (heterogeneous systems) will occur iii other systems from which it may be difficult to discern the monolayer, one is forced to the conclusion that final judgment of the accuracy of the B.E.T. method... 

Reactions with bis(dialkylainino)difluoro-/l.4 -sulfanes can be performed in normal glassware under anhydrous conditions. Caution in the presence of moisture hydrolysis takes place liberating hydrogen fluoride. Bis(dialkylamino)difluoro-24 -sulfanes are less reactive fluorinating reagents than (dialkylamino)trifluoro-24 -sulfanes. This fact coupled with their lengthier syntheses and their noncommercial availability has limited their application. 

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