Catechins inhibition

Studies focused on the determination of SAR have revealed that the different enantiomeric form of catechins apparently affects their antibacterial activity. Bais et al. [101] found that (-i-)-catechin inhibited soil-borne bacteria of the species Xanthomonas campestris, R fluorescens, and Erwinia caro-... 

Numerous studies were dedicated to the effects of flavonoids on microsomal and mitochondrial lipid peroxidation. Kaempferol, quercetin, 7,8-dihydroxyflavone and D-catechin inhibited lipid peroxidation of light mitochondrial fraction from the rat liver initiated by the xanthine oxidase system [126]. Catechin, rutin, and naringin inhibited microsomal lipid peroxidation, xanthine oxidase activity, and DNA cleavage [127]. Myricetin inhibited ferric nitrilotriacetate-induced DNA oxidation and lipid peroxidation in primary rat hepatocyte cultures and activated DNA repair process [128]. 

Gradisar H, Pristovsek P, Placer A, Jerala R. (2007) Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site. 7 Med Chem 50 264-271. 

Kuzuhara T, Iwai Y, Takahashi H, Hatakeyama D, Echigo N. (2009) Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase. PLoS Curr Influenza RRN1052. 

Blache D, Durand P, Prost M, Loreau N. 2002. ( + )-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. Free Radic Biol Med 33 1670-1680. 

Catechin, isolated from the bark of Ceiba pentandra, inhibits COX-1 with an IC50 value of 80 pM [196]. Commercially available pure (+)-catechin inhibits COX-1 with an IC50 value of around 183 to 279 pM depending upon the experimental conditions, with no selectivity for COX-2 [17]. 

Lamy, S., Gingras, D., and Beliveau, R., Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation, Cancer Res., 62, 381-385, 2002. 

Dopamine is oxidised by peroxynitrite (molar ratio 1 1) to 6-hydroxyindole-5-one as characterised by HPLC and photodiode array spectra, akin to the products of the tyrosinase-dopamine reaction, but no evidence of dopamine nitration was obtained (Kerry and Rice-Evans 1999). Although peroxynitrite did not cause nitration of dopamine in vitro, the catecholamine is capable of inhibiting the formation of 3-nitrotyrosine from peroxynitrite-mediated nitration of tyrosine. The plant-derived phenolic compounds, caffeic acid and catechin, inhibited peroxynitrite-mediated oxidation of dopamine. In contrast, the monohydroxylated hydroxy-... 

Catechins inhibited invasion of mouse MO4 cells into embryonic chick heart fragments in vitro (Bracke et al. 1991). The anti-invasive effects could be ranked as follows ... 

Leong H, Mathur PS, Greene GL (2009) Green tea catechins inhibit angiogenesis through suppression of STAT3 activation. Breast Cancer Res Treat 117 505-515... 

Osada K, Takahashi M, Hoshina S, Nakamura M, Nakamura S, Sugano M. Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 2001 128 153-164. 

Weyant MJ, Carothers AM, Dannenberg AJ, Bertagnolli MM. (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. Cancer Res 2001 61 118-25. 

---