Peroxynitrite-mediated oxidation

Kooy NW, Royall JA, Ischiropoulos H and Beckma JS. 1994. Peroxynitrite-mediated oxidation of dihy-drorhodamine 123. Free Radic Biol Med 16(2) 149-156. 

Santos MR and Mira L. 2004. Protection by flavonoids against the peroxynitrite-mediated oxidation of dihydrorhodamine. Free Radic Res 38(9) 1011-1018. 

Ferroni, F., Maccaglia, A., Pietraforte, D., Turco, L., and Minetti, M., Phenolic antioxidants and the protection of low density lipoprotein from peroxynitrite-mediated oxidations at physiologic CO2, J. Agric. Food Chem., 52, 2866, 2004. 

Denicola A, Freeman BA, Trujillo M, Radi R (1996) Peroxynitrite reaction with carbon dioxide/bicar-bonate kinetics and influence on peroxynitrite-mediated oxidations. Arch Biochem Biophys 333 49-58... 

Zhang H, SquadritoGL, Uppu RM, Lemercier J-N,Cueto R, Pryor WA (1997) Inhibition of peroxynitrite-mediated oxidation of glutathione by carbon dioxide. Arch Biochem Biophys 339 183-189... 

Douki T, Cadet J (1996) Peroxynitrite mediated oxidation of purine bases of nucleosides and isolated DNA. Free Rad Res 24 369-380... 

Kooy N., Royall J., Ischoropoulos H., and Beckman J. (1994). Peroxynitrite-mediated oxidation of dihydiorhodamine 123. Free Radic. Biol. Med. 16 149-156. 

We have recently shown that the peroxynitrite-mediated oxidation of oxyMb and oxyHb proceeds via intermediate oxoiron(iv) (ferryl) complexes, which, in a second step, react further with peroxynitrite to yield metMb and metHb, respec-... 

A17. Arteel, G. E., Mostert, V., Oubrahim, H., Briviba, K., Abel, J., and Sies, H., Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration. Biol. Chem. 379, 1201-1205 (1998). 

G5. Gatti, R. M., Radi, R., and Augusta, O., Peroxynitrite-mediated oxidation of albumin to the protein-thiyl free radical. FEBS Lett. 348,287—290 (1994). 

Ischiropoulos, H., and al-Mehdi, A. B., Peroxynitrite-mediated oxidative protein modifications. FEBSLett. 364, 279-282 (1995). 

Sies, H., Sharov, V. S., Klotz, L. O., and Briviba, K., Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase. J. Biol Chem. 272, 27812-27817 (1997). 

Aoyama K, Matsubara K, Fujikawa Y, Nagahiro Y Shimizu K, Umegae N, Hayase N, Shiono H, Kobayashi S (2000) Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegen-erative diseases. Ann Neurol 47 524-527. 

Szab6 C, Sabman AL, Ischiropoulos H. Peroxynitrite-mediated oxidation of dihydrorhodamme 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS Utt 1995 372 229-232. 

Szabo C, Salzman AL, Ischiropoulos H. Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occuis in early sc s of endotoxic and hemorrht c shock and ischemia-repeifusion injury. FEBS Lett 1995 372 229-32. 

Dopamine is oxidised by peroxynitrite (molar ratio 1 1) to 6-hydroxyindole-5-one as characterised by HPLC and photodiode array spectra, akin to the products of the tyrosinase-dopamine reaction, but no evidence of dopamine nitration was obtained (Kerry and Rice-Evans 1999). Although peroxynitrite did not cause nitration of dopamine in vitro, the catecholamine is capable of inhibiting the formation of 3-nitrotyrosine from peroxynitrite-mediated nitration of tyrosine. The plant-derived phenolic compounds, caffeic acid and catechin, inhibited peroxynitrite-mediated oxidation of dopamine. In contrast, the monohydroxylated hydroxy-... 

Selenium compounds are more active electron donors compared to analogous sulphur compounds and play a wide role in biochemical systems. They can decompose peroxides (Caldwell and Tappel 1964,1965) and can act as antioxidants (Dillard et al. 1978) and free radical scavengers (Ursini and Bindoli 1987). Masumoto and Siess (1996) and Masumoto et al. (1996) have shown that peroxy-nitrite rapidly oxidises ebselen and its main metabolite to the corresponding selenoxides. The results of Padmaja et al. (1997) suggest that CO2 partially protects methionine selenoxide from peroxynitrite-mediated oxidation and that 0=N-00-C02 or its derivatives do not mediate the oxidation of d,l-selenomethionine or methionine selenoxide. 

Kerry N, Rice-Evans C. Inhibition of peroxynitrite-mediated oxidation of dopamine by flavonoid and phenolic antioxidants and their stmctural relationships. J Neurochem 1999 73 247-253. 

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