Combinatorial chemistry high throughput catalysis

The often used synonym combinatorial catalysis instead of high-throughput catalysis implies that all possible combinations of all parameters that can affect catalyst performance (precursor compounds, chemical composition, synthesis protocol, calcination,. ..) will be screened to find the best suited catalyst for the reaction. Although such strategies are used in combinatorial chemistry, it is almost impossible to adapt them to heterogeneous catalysis. 

The best combination turned out to be L5 /A9 (ee = 90% at room temperature and 99% at —78 °C with benzaldehydes and ee = 92-99% with other aldehydes).87 Further improvements were reported later.89 Although only a few dozen reactions were monitored by a JASCO-CD-995 instrument, the CD-based assay is amenable to high-throughput screening of enantioselective catalysts. The chemistry itself lends itself ideally to combinatorial asymmetric metal catalysis, since the principle of asymmetric activation is turning out to be very powerful.89... 

The implementation of combinatorial chemistry and automated methods for rapid synthesis, testing, and characterization of catalysts, has opened a wide range of new opportunities in catalysis. However, so far, Mossbauer spectroscopy has not been introduced into this methodology. Two hurdles must be overcome for Mossbauer spectroscopy to become important in high-throughput catalyst characterization the system for recording spectra must be scaled down, and the data acquisition and exploitation systems must be adapted. 

Uozumi, Y., Hayashi, T. Solid-phase palladium catalysis for high-throughput organic synthesis. Handbook of Combinatorial Chemistry 2002, 1,531-584. 

A.S.C. (2002) Chemical Reviews, 102, 3385. For a recent review of solid-phase reactions using palladium catalysts, see (a) Uozumi, Y. and Hayashi, T. (2002) Solid-phase palladium catalysis for high-throughput organic synthesis, in Handbook of Combinatorial Chemistry (eds K.C. Nicolaou, R. Hanko and W. Hartwig), Wiley-VCH Verlag GmbH, Weinheim, Chapter 19, pp. 531-584. 

Koyama, M., Tsuboi, H., Endou, A., Takaba, H., Kubo, M., Del Carpio, C.A. and Miyamoto, A. (2007). Combinatorial computational chemistry approach for materials design Applications in deNOx catalysis, Fischer-Tropsch synthesis, lanthanoid complex, and lithium ion secondary battery. Comb. Chem. High Throughput Screening, 10, 2,99-110. 

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