Carvacrol

Thymoquinone has been prepared directly from thymol by sulfonating and oxidizing the sulfonation mixture with manganese dioxide or potassium dichromate the same process has been successfully applied to carvacrol. The oxidation of sa ts of aminothymol with dichromate, ferric chloride, or nascent bromine also leads to satisfactory yields of thymoquinone. The above procedure is based on the observation that the diazonium salt obtained from aminothymol is almost quantitatively con-... 

TLC chloroform HPTLC toluene (for carvacrol/thymol separation). 

Detection and result The following hRf values (TLC, chloroform) were obtained carvacrol and thymol (red) 30—35, eugenol (salmon pink) 40 — 45 here the background was pale yellow colored. The visual detection limit was 200 — 500 ng per chromatogram zone. The colored zones faded after 1 to 2 hours. 

The oil CQuialna abont 70 to dO pec cent, of phenols, of which a small portion consists of carvacrol aod the remainder of thymol, the rest of the oil being chiefly cymene, which bolls at 17o to 176 U., whilst thymol boils at 232 C. 

Tne oil thus tnvited vea a cooameruiivl peld of 00 3 per ceut. of thymol of a perf<.-ct)y white crystslliue character. Carvacrol it also probably reseut in the oil, as well as cymene, and traces o d-HmonenP.. 

Th oil coQlains a eonsidernhle amonnt of carvacrol, with a little thymol. l hynii -liydroquinooe is algo present, and probably oitral and cymene,... 

Id the esthnatiou of carracrol a slight modiheatioo of this method EDDst he made, because carvacrol le thiot n down as a finely diyided white precipitate, giving the solution a milky appearance, lu order to form a precipitate the liquid is vigorously shaken after the addiliou of iodiue solution, and is sntiseqnently filtered. Then the liquid ia acidn-lated with hydrochloric acid, aud subsequently the same procedure is followed as was described lor thymol. The calculatiou is also the same. 

The od is soluble iu 3 volumes of 70 per cent, alcohols, The phenols consist almost entirely of carvacrol, and there are also preaeut cymene and terpenes. 

Aii ail exaiBiO jd by. Jahns, htivio a speoifio gravity 0-393, was [ouad to contain 30 per Qtol. o( carvacrol, with icaQ a o[ a second pbanol, cvm inc an,-l oni or more lerpeoes. 

Carvacrol and eyentoeare the principal cncetitoents o[ the oil. -9alureja Ih irnhri yields an esssnlial oil having the [ollowing ahac-... 

The Japanese plant Hoaia Japonica yields about 2 per cent, of eeaential oil containing 44 per cent, of thymol. Its specific gravity is abont 0 J20. Uuryama baa identified thymol, carvacrol, and pinene... 

Hoshlno states that aJthongh thymol and carvacrol ate constituents of tbe oil, they are never found togethei in tbe same oil, A thymol containing oil had the following eharactors —... 

This aldehyde is identical with the naturally occurring phellandral, an aldehyde found in oil of water fennel. If the nitrosochloride of /3-phellandrene be decomposed by acetic acid, dehydrocuminic aldehyde and carvacrol result. 

When distilled with phosphorus pentoxide, camphor yields cymene, and with iodine, carvacrol. Both of these bodies are para-derivatives of benzene. On oxidation with nitric acid camphor yields many acids, of which the chief are camphoric acid, CjgHjgO, camphanic acid, CjoHj O, and camphoronic acid, CgHj Og. The constitution of these acids has an important bearing on that of camphor. Many formulae have been suggested for camphor during the past few years, but that of Bredt is now universally accepted, and has received complete confirmation by Komppa s synthesis of camphoric acid. This synthesis confirms the formula for camphoric acid as—... 

Thymol frequently occurs associated with carvacrol, its wtfio-isomer, and may be separated therefrom by fractional crystallisation of the phenyltirethanes, that of carvacrol being much less soluble in petroleum ether than that of thymol. 

It is interesting to note that thymol, as well as its isomer carvacrol can be removed from its alkaline solution either by distillation by steam, or by repeated extraction by ether... 

Carvacrol, Cj Hj O, is a phenol isomeric with thymol, with which it is frequently found associated, especially in certain types of thyme and origanum oils. 

Carvacrol is isopropyl-orfAo-cresol, of the following constitution —... 

Carvacrol is a colourless liquid, with a fragrant odour, solidifying, when quite pure, in the cold. 

If carvacrol be treated, in alcoholic potash solution, with amyl nitrite, nitrosocar acrol, CgH2(CHa)(OH)(C3Hj)(NO), results. This body forms well-defined crystals melting at 153°. 

By heating carvacrol with alkalis, it is converted into isocuminic-acid, C(jH3(C3Hy)(OH)(COOH), melting at 93°. By oxidation with chromic acid mixture, thymoquinone results. This compound forms-crystalline tables melting at 45° to 46°. 

Carvacrol is a naturally occurring substance isolated from oregano, thyme, and marjoram. What is its TUPAC name ... 

Heating carvone wilh aqueous sulfuric acid converts it into carvacrol. Propose a mechanism for the isomerization. 

Detection and result The following hi carvacrol and thymol (red) 30—35, eu ground was pale yellow colored. The chromatogram zone. The colored zom... 

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