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Cardiotoxicity screening

MordwinkinNM, Burridge PW, Wu JC (2013) A review of human pluripotent stem cell-derived cardiomyocytes for high-throughput drug discovery, cardiotoxicity screening, and publication standards. J Cardiovasc Transl Res 6(1)22-30... [Pg.75]

Peters, M.F., Lamore, S.D., Guo, L., Scott, C.W., Kolaja, K.L. (2015). Human stem cell-derived cardiomyocytes in cellular impedance assays bringing cardiotoxicity screening to the front hue. Cardiovascular Toxicology, 15, 127—139. [Pg.25]

Himmel HM (2013) Drug-induced functional cardiotoxicity screening in stem ceU-derived human and mouse cardiomyocytes effects of reference compounds. J Pharmacol Toxicol Methods 68 97-111... [Pg.195]

Heart (cardiotoxicity) [86] Hundred compounds were screened for the effect on the heart rate by 15-s video recordings in 2 dpf zebrafish embryos. Of 23 drugs that were known to cause repolarization abnormalities in human, 22 were also positive in zebrafish embryos. [Pg.258]

As shown in Chap. 8, WBZ 4 is a re-engineered version of imatinib with an enhanced specificity needed to curb imatinib s potential cardiotoxicity. The inhibitory impact of WBZ 4 is restricted to KIT, PDGFR, and JNK, all with nanomolar affinity, as corroborated by screening against a T7-bacteriophage library of kinase displays (Ambit Biosciences, CA) [13],... [Pg.201]

Stoelzle S, Haythomthwaite A, Kettenhofen R et al (2011) Automated patch clamp on mESC-derived cardiomyocytes for cardiotoxicity prediction. J Biomol Screen 16(8) 910-916... [Pg.73]

Screening for Cardiotoxicity. Early detection of potential for adverse cardiovascular effects has become increasingly important with the recognition of the clinical risks associated with increased prolongation of the QT... [Pg.627]

Doherty KR, Talbert DR, Trusk PB, Moran DM, Shell SA and Bacus S (2015) Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types. Toxicol Appl Pharmacol. 285(l) 51-60. [Pg.8]

Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA and Rusyn I (2013) Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. Toxicol Appl Pharmacol. 273(3) 500-7. [Pg.11]

S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC, Wu JC (2013). Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation 127 1677-1691. [Pg.155]

See other pages where Cardiotoxicity screening is mentioned: [Pg.124]    [Pg.188]    [Pg.194]    [Pg.124]    [Pg.188]    [Pg.194]    [Pg.388]    [Pg.395]    [Pg.313]    [Pg.307]    [Pg.165]    [Pg.455]    [Pg.74]    [Pg.76]    [Pg.473]    [Pg.565]    [Pg.609]    [Pg.253]    [Pg.565]    [Pg.355]    [Pg.356]    [Pg.359]    [Pg.377]    [Pg.195]    [Pg.53]    [Pg.63]    [Pg.149]   
See also in sourсe #XX -- [ Pg.2 , Pg.627 ]

See also in sourсe #XX -- [ Pg.627 ]



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