Cardenolide glycoside

An isomeric sugar, D-javose, is a constituent of two cardenolide glycosides (strophanthojavoside and antiarojavoside) found (42) in the seeds of Antiaris toxicaria Lesch. Degradative studies indicated (42) that javose had the structure 6-deoxy-2-0-methyl-D-allose (17) and this assignment was confirmed by two stereospecific syntheses. 

Blood/gout/ digitonin/ cardenolide glycoside/aiding the solubilization of... 

D-Boivinose (2,6-dideoxy-D-vy/o-hexose, 42D) was described as component of a cardenolide glycoside isolated from the seeds of Corchorus olitorius L. The structure was established as cannogenol 3-<9-(3-D-glucopyranosyl-<9-(3-D-boivinopyranoside.105... 

T. Nakamura, Y. Goda, S. Sakai, K. Kondo, H. Akiyama, and M. Toyoda, Cardenolide glycosides from seeds of Corchorus olitorius, Phytochemistry, 49 (1998) 2097-2102. 

T. Yamauchi, F. Abe, and A. S. C. Wan, Studies on Cerbera. IV. Polar cardenolide glycoside from the leaves of Cerbera odollam and Cerbera manghas, Chem. Pharm. Bull. (Tokio), 35 (1987) 4813-4818. 

Hamed, A.I., Plaza, A., Balestrieri, M.L., Mahalel, U.A., Springuel, I.V., Oleszek, W., Pizza, C. and Piacente, S. (2006) Cardenolide glycosides from Pergularia tomen-tosa and their proapoptotic activity in Kaposi s sarcoma cells. /. Nat. Prod., 69, 1319-22. 

Laphookhieo, S., Cheenpracha, S., Karalai, C., Chantrapromma, S., Rat-a-pa, Y, Ponglimanont, C. and Chantrapromma, K. (2004) Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam. Phytochem., 65, 507-10. 

Luta, M., Hensel, A. and Kreis, W. (1997) p-D-Fucosidase and other cardenolide glycoside-modifying enzyme in Digitalis lanata EHRH, in 45th Annual Congress on Medicinal Plant Research, Regensburg. 

Seidel, S. and Reinhard, E. (1987) Major cardenolide glycosides in embryogenic suspension cultures of Digitalis lanata. Planta Med., 3, 308-9. 

Cephalantus natalensis Oliv. [umfomfo, tree strawbeny] (Rubiaceae) root bark decoction is nsed for infertility in women and to increase libido. The root bark contains alkaloids, cardenolides, glycosides, polyphenols and taimins 18). The fresh beny is eaten for malaria fever 28). The root bark contains alkaloids, cardenolides, glycosides, polyphenols and tannins 18). 

Cyathea dregei Kunze [licimamlilo, grassland tree fern] (Cyatheaceae) bark decoction is used for chancroid. The bark contains cardenolides, glycosides, polyphenols and terpenoids (18). 

Annona senegalensis stem bark is used for the treatment of hysteria and a constituent of its root bark has been found efiective for treating cancer using sarcoma 180 ascites cells (75). The bark and root are used in the treatment of sexually transmitted diseases (18). The root bark contains cardenolides, glycosides and saponins. The stem bark contains anthranoids, cardenolides, glycosides saponins and terpenoids (50,18). Its fraits are edible and are taken for diarrhoea, dysentery and vomiting (23,33). 

Cardenolide glycosides Apply bands of sample solution contaimng ca 25 pg glycoside, cover the layer, apart from the apdication zones, with a glass plate and place in [36, 37]... 

Erysimi herba (1) has two cardenolide glycoside zones above and two zones below test TT with e.g. erysimoside (R, 0.2) and helveticoside (R, — 0.5). 

For instance, cardenolide glycosides, such as 2 -acetylneriifolin, exhibited a specific pattern of cytotoxic activity in the NCI panel of cell lines (54). Certain cell lines, particularly those among the non-small-cell lung, brain tumor, and renal-cell lines are exceptionally sensitive to 2 -acetylneriifolin, whereas most of the leukemia and colon cell lines were less sensitive to it. From the similar pattern of activity produced by crude extracts of plants of the classes Apocyanaceae and Asclepiadaceae, NCI scientists concluded in this study that similar cardenolide glycosides are present in these extracts. 

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