Carcinogens lethality

Propylene oxide is a primary irritant, a mild protoplasmic poison, and a mild depressant of the central nervous system. Skin contact, even in dilute solution (1%), may cause irritation to the eyes, respiratory tract, and lungs. Propylene oxide is a suspected carcinogen in animals. The LC q (lowest lethal concentration by inhalation in tats) is 4000 mg/kg body weight. The LD q (oral) is 930 mg/kg. The LD q (dermal) is 1500 mg/kg. The TWA (8-h exposure) is 100 ppm and the STEP (15-min exposure) is 150 ppm. 

Lazar (http //lazar.in silico.de/predict) is a k-nearest-neighbor approach to predict chemical endpoints from a training set based on structural fragments [43]. It derives predictions for query structures from a database with experimentally determined toxicity data [43]. Model provides prediction for four endpoints Acute toxicity to fish (lethality) Fathead Minnow Acute Toxicity (LC50), Carcinogenicity, Mutagenicity, and Repeated dose toxicity. 

Dinse, G.E. (1985). Estimating Tumor Prevalence, Lethality and Mortality, Presented at the Symposium on Long-Term Animal Carcinogenicity Studies A Statistical Perspective, March 4-6, 1985, Bethesda. 

The compound is poisonous by intravenous route and a carcinogen intravenous lethal dose in rat is about 4 mg/kg. 

Vogel, E., Blijleven, W.G.H., Kortselius, M.J.H. and Zijlstra, J.A. (1981) Mutagenic activity of 17 coded compounds in the sex-linked recessive lethal test in Drosophila melanogaster, in Progress in Mutation Research, Volume 1 Evaluation of Short-Term Tests Carcinogens (eds F.J. de Serres and J. Ashby), Elsevier, Amsterdam. 

Despite widespread use as an Insecticide, nematoclde, and Intermediate In chemical processes, the toxic potential of PS has not been fully evaluated. Absence of lethal effects may well be explained by Its powerful odor, which alerts workers to Its presence In contaminated areas. Anlmal-toxlclty data suffer from variations In the methods used. One long-term study of carcinogenicity In rats was unsatisfactory because of high early mortality. 

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