Carcinogenic compounds Quercetin

The ability of flavonoids to act as pro-oxidants in vitro and in cell systems has also been suggested to be a potential mechanism by which they may act as anti-carcinogenic compounds in vivo as a result of their abilities to promote death of cancer cells. Quercetin has been thoroughly investigated for its abilities to express antiproliferative effeets [100,103,108,109] and induee death predominantly by an apoptotie meehanism in eaneer eell lines [95,97-99,102-105,110-116]. For example, the exposure of quereetin and the isoflavone genistein to the eolonie... 

By using the hepatocyte primary culture DNA repair test [247] with liver cells of adult ACI rats, an essay that is capable to discern true carcinogens from solely mutagenic compounds such as quercetin and other bioactive flavonoids, Japanese workers [248] were able to show that ptaquiloside is a genotoxic carcinogen. The key evidence was that ptaquiloside induced DNA repair in the exposed liver cells, which could be interpreted as an intrusion into the DNA molecule that caused enough distortions to trigger the reconstruction mechanism. 

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