Carcinogenesis free radical mediated

Peroxides can play a physiological role in the cell but also mediate processes leading to heart disease and carcinogenesis. Fatty acid peroxidation may also be related to free radical-mediated metabolic activation of carcinogens or drugs, which lead to the initiation of carcinogenesis or cytotoxicity. Modification of membrane function as a consequence of lipid peroxidation includes imcoupling of oxidative phosphorylation... 

A82a. O Brien, P.J. Free-radical-mediated chemical carcinogenesis Arm. N.Y. Acad. Sci. 534 (1988) 552-564. 27A98. 

Oxygenated acylglycerols. Lipid peroxidation in biological tissues attracts much attention because of its possible contribution to the functional modulation of biomembranes and lipoproteins. It is believed to be involved in free-radical-mediated damage, carcinogenesis and ageing processes. Research requires specific, sensitive and reproducible procedures to quantify the lipid hydroperoxides in each lipid class as primary products and the alcohols and aldehydes as secondary products of the peroxidation reaction. The identification and quantification of lipid oxidation products is therefore of great practical and theoretical interest and MS has assumed a major role in these analyses as a result of the development of mild ionization techniques. 

Guyton, K. Z. Bhan, P. Kuppusamy, P. Zweier, J. L. Trush, M. A. Kensler, T. W. Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide expanded role for electrophiles in multistage carcinogenesis. Proc. Natl. Acad. Sci. USA 1991, 88, 946-950. 

Mamett, L.J. (1987) Peroxyl free radicals potential mediators of tumor initiation and promotion. Carcinogenesis 8, 1365-1373. 

Han, X. Liehr, J.G. Microsome-mediated 8-Hydroxylation of guanine bases of dna by steroid estrogens correlation of DNA damage by free radicals with metabolic activation to quinones. Carcinogenesis 1995, 16, 2571-2574. 

Rousseau, E.J., Davison, A.J. and Dunn, B. (1992) Protection by yS-carotene and related compounds against oxygen-mediated cytotoxicity and genotoxicity implications for carcinogenesis and anticarcinogenesis. Free Radical Biol. Med. 13 407-433. 

Athar, M., Agarwal, R., Wang, Z.Y., Lloyd, J.R., Bickers, D.R., and Mukhtar, H., All trans retinoic acid protects against free radical generating compounds-mediated conversion of chemically and ultraviolet B radiation-induced skin papillomas to carcinomas. Carcinogenesis, 12, 2325-2329, 1991. 

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