Carboxylic acids acid chloride synthesis

Esterification (Section 17.7A) The synthesis of an ester, usually involving reactions of carboxylic acids, acid chlorides or acid anhydrides with alcohols. 

Hydrolytic reactions can also be applied in the synthesis of aldehydes or ketones via the corresponding 1,3-oxazine derivatives. The anion formed from 3-methyl-2-(4-pyridyl)tetrahydro-l,3-oxazine 155 on treatment with BuLi proved to react with various electrophiles (alkyl halides, carboxylic esters, acid chlorides, or aldehydes) exclusively at position 2 of the 1,3-oxazine ring and not at the pyridine nitrogen atom. The readily formed 2,2-disubstituted-l,3-oxazine... 

The Strecker synthesis is used to prepare amino acids in the laboratory. As shown in the following equation, an aldehyde is reacted with sodium cyanide and ammonium chloride in water to produce a cyanoamine. Conversion of the cyano group to a carboxylic acid completes the synthesis. Show the structure of the intermediate, A, in the following synthesis, and show the steps in the mechanism for the formation of A and for the conversion of A to the cyanoamine. (Hint Remember that NH4+ and H,0 are in equilibrium with NH3 and H-0+.)... 

Aluminum chloride Carboxylic acids from hydrocarbons Synthesis with addition of 1 C-atom s. 4, 802 AIClt H —COOH... 

The synthesis of carboxylate-substituted imidazoline derivatives has previously been accomplished by the condensation of presynthesized 1,2-diamines with amides, or through the transition metal catalyzed aldol-type reaction between isocyanates and imines (4,5). We have recently communicated an alternative palladium catalyzed route to synthesize a new class of imidazoline carboxylates, utilizing acid chloride, imines and carbon monoxide as starting materials (see Table 1)... 

Lithium-halogen exchange. The direct synthesis of ketones from carboxylic acids, organic chlorides and LN is quite useful. The cyclization of 1,4-diiodobutane derivatives is the basis of an approach to cyclobutyl ketones. ... 

Variations of this reaction have been applied over the years, typically involving the condensation of 2-aminothiophenols with substituted carboxylic acids, acyl chlorides, aldehydes, and nitriles. Initially, the reaction involves the formation of an imine that cyclizes spontaneously and then oxidation to form benzothiazole. An application of this chemistry has been showcased in the synthesis of 2-(4-aminophenyl)benzothiazoles and the evaluation of their in vitro and in vivo activities against breast cancer cell lines, with compound a exhibiting the most potent growth inhibition. Unfortunately, there are limitations due to the difficulties met during the syntheses of readily oxidizable o-aminothiophenol-bearing substituents. 

The customary method for the laboratory synthesis of acid anhydrides is the reac tion of acyl chlorides with carboxylic acids (Table 20 1)... 

The chemical inertness of the three-membered ring permitted many conversions of functional groups in diazirines. Esterifications, cleavage of esters and acetals, synthesis of acid chlorides, oxidation of hydroxy groups to carboxyl groups as well as Hofmann alkenation all left the three-membered ring intact (79AHC(24)63). 

Chromone-2-carbaldehyde, 3-methyl-synthesis, 3, 709 Chromonecarbaldehydes Knoevenagel condensation, 3, 711 Chromone-3-carbaldehydes mass spectra, 3, 615 oxidation, 3, 709 reactions, 3, 712 Schiff bases, 3, 712 synthesis, 3, 821 Chromone-2-carbonyl chloride Grignard reaction, 3, 711 Chromonecarboxamide, N-tetrazolyl-antiallergic activity, 3, 707 Chromone-2-carboxylic acid, 3-chloro-ethyl ester... 

Furan-2-carbonyl chloride, 5-alkyl-3,4-dichloro-synthesis, 4, 690 Furancarboxamides rotational isomerism, 4, 543 Furan-2-carboxylic acid, 5-acetylamino-ethyl ester reactions, 4, 647 Furan-2-carboxylic acid, amino-properties, 4, 708 Furan-2-carboxylic acid, 5-bromo-nitration, 4, 603, 711 Furan-2-carboxylic acid, 3-methyl-methyl ester bromination, 4, 604 Furan-2-carboxylic acid, 5-methyl-nitration, 4, 602... 

Indole-2-carboxylic acid, 5-bromo-l-hydroxy-tautomerism, 4, 197-198 Indolecarboxylic acid chloride synthesis, 4, 288... 

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