Carboranes medicine

Nitrene cycloaddition was also used by Yinghuai and co-workers to append C2B10 carborane cages to SWCNTs [31]. One of the derivatives showed very interesting potential in medicinal applications as it was found that boron atoms had higher concentrations in tumor cells than in blood or other organs when administered to mice. This finding could inspire further research on the use of these systems as nanovehicles for... 

The rapid development of carborane chemistry is mainly due to their practical applications. For instance, the potential utility of carborane polymers as gaskets, O-rings, and electrical connector inserts has been reported. Their functionality for solvent extraction of radionuchdes as well as the potential medicinal value of the isoelectronic and isostructural boron analogues of biologically important molecules has been the subject of many review articles. For example, a number of boron compounds have been found to possess anti-inflammatory and antiarthritic activity in animal model studies. Boron compounds have also been implicated in studies designed to probe the importance of the so-called anionic subsite of acetylcholine esterase and Ach receptors. But, by far the most interesting practical apphcations of carboranes are in areas of boron neutron capture therapy (BNCT) and supramolecular assembly. 

A New Medicinal Application of Boron Clusters. Potent Nuclear Receptor Ligands Bearing Carborane as a Hydrophobic Pharmacophore... 

Covering many areas of chemistry with boron at its centre, topics include applications to polyolefin catalysis, medicine, materials and polymers boron cluster chemistry, including carboranes and metal-containing clusters organic and inorganic chemistry of species containing only 1 or 2 boron atoms and theoretical studies of boron-containing compounds. New materials with novel optical and electronic properties are also discussed. 

Contemporary Boron Chemistry contains 80 reports in nine chapters. Clearly, since much research is interdisciplinary in nature, our decision to include a report in one particular section rather than another was sometimes an arbitrary one. With this caveat in mind, the sections are as follows Applications to Polyolefin Catalysis Materials and Polymers Medicinal Applications Cluster Synthesis Carboranes Metallaboranes Metallaheteroboranes Organic and Inorganic Chemistry of Mono- and Di-boron Systems and Theoretical and Computational Studies. 

Medicinal chemistry in the new millennium. A glance into the future 02PAC703. Medicinal chemistry of carboranes 02CCR(232)173. 

Since the time of the aforementioned reviews, more recent advances in the chemistry of boron therapeutics have been covered by others (2009MI1275). Advances in the chemistry of azaborines have been reviewed recently (2012AG(I)6074), as have those in the medicinal chemistry of boronic acid derivatives, 1,2-azaborines, and icosahedral boranes (carboranes) (2013AJC1118). Advances in the chemistry of tetrahedraUy coordinated B-heterocycles have been reviewed (2000CCR85), and advances in luminescent dyes containing tetrahedral boron centers... 

A. F. Armstrong, J. F. Valiant, The bioorganic and medicinal chemistry of carboranes From new drug discovery to molecular imaging and therapy, Dalton Trans., 2007, 4240-4251. 

Y. Endo, T. lijima, Y. Yamakoshi, H. Fukasawa, C. Miyaura, M. Inada, A. Kubo, A. Itai, Potent estrogen agonists based on carborane as a hydrophobic skeletal structure. A new medicinal application of boron clusters, Chem. Biol., 2001, 8, 341-355. 

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