Carba-sugars chemistry

CHEMISTRY OF CARBA-SUGARS (PSEUDO-SUGARS) AND THEIR DERIVATIVES... 

The increasing number of unusual carba-sugars and their presumably forthcoming derivatives will make the chemistry of carba-sugars an important new field of chemistry. 

Carba-sugars (pseudo-sugars) and their derivatives, chemistry of, 48, 21 - 90 Carbohydrate chemistry anomeric and exo-anomeric effects in, 47, 45-123... 

T. Suami and S. Ogawa, Chemistry of carba-sugars (pseudo-sugars) and their derivatives, Adv. Carbohydr. Chem. Biochem., 48 (1990) 21-90. 

Suami, T. et al. Chemistry of Carba-Sugars (Pseudo-Sugars) and Their Derivatives. 1990[25b]... 

The chemistry of carba sugars is quite similar to that of cyclitols both groups lack the latent carbonyl groups of their saccharide counterparts, and therefore fail to exhibit many of the characteristic properties of monosaccharides. Thus carba sugars and cyclitols do not form hydrazones or osazones, nor do they mutarotate, or reduce heavy-metal salts in base, in contrast to their oxidation products, the inososes. 

Vasella has reviewed the chemistry of glycosyl carbanions, carbocations, radicals and carbenes and related work covering his own important contributions and those of others. Specific areas to have been reviewed are carba-sugars (with ring oxygen atoms replaced by carbon), the enediyne anticancer antibiotics notably calicheamycin and esperamycin (Nicolaou s synthetic work on the disaccharide component especially). ... 

This chapter will review the recent developments in nucleoside research both in term of chemistry and potential medical use. We will first review modifications brought to the ribose or 2 -deoxyribose moiety of a nucleoside, from C-1 to C-5 (nucleoside nomenclature). We will then look at publications on ribose replacement with unnatural sugars, including carba, thia and aza sugars, and then we will review the literature on bicyclonucleosides published in recent years. This chapter will be concluded with a review of recent articles on nucleoside synthesis on solid support, and the challenges associated with this technique applied to nucleoside synthesis. 

Reviews have appeared on carba-amino sugars and their a-glucosidase inhibitory activity, and on the chemistry and enzymic preparation of complex chiral and bio-active azamono- and oligo-saccharides and their derivatives. ... 

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