Captopril NSAIDs

Examples chlorpropamide, lithium, captopril, NSAIDs, fluoride, diuretics, ACE inhibitors... 

Allopurinol, barbiturates, benzodiazepines, captopril, carbamazepine, erythromycin, fluoroquinolones, isoniazid, NSAIDs, penicillins, phenothiazines, phenytoin, rifampin, sulfonamides antimicrobials, and tetracyclines... 

Nephrotoxicity is caused by drugs that principally affect the renal hemodynamics of the patient depended on vasodilator prostaglandin biosynthesis or angiotensin converting enzyme (ACE) mediated vasoconstriction drugs causing nephrotoxicity include NSAIDs (fenprofen), ACE inhibitors (captopril, and cyclosporin). 

ANTI HYPERTENSIVES AND HEART FAILURE DRUGS NS AIDs 1 hypotensive effect, especially with indometacin. The effect is variable amongst different ACE inhibitors and NSAIDs, but is most notable between captopril and indometacin NSAIDs cause sodium and water retention and raise BP by inhibiting vasodilating renal prostaglandins. ACE inhibitors metabolize tissue kinins (e.g. bradykinin) and this may be the basis for indometacin attenuating hypotensive effect of captopril Monitor BP at least weekly until stable. Avoid co administering indometacin with captopril... 

ACE INHIBITORS, ANGIOTENSIN II RECEPTOR ANTAGONISTS ASPIRIN t risk of renal impairment. 1 efficacy of captopril and enalapril with high-dose (>100mg/day) aspirin Aspirin and NSAIDs can cause elevation of BP. Prostaglandin inhibition leads to sodium and water retention and poor renal function in those with impaired renal blood flow Monitor renal function every 3-6 months watch for poor response to ACE inhibitors when >100mg/day aspirin is given... 

Clinically important, potentially hazardous interactions with ACE inhibitors, alcohol, amiloride, barbiturates, benazepril, captopril, cyclosporine, enalapril, fosinopril, juniper, lisinopril, mitotane, moexipril, narcotics, NSAIDs, potassium chloride, potassium iodide, quinapril, ramipril, trandolapril, triamterene, zofenopril... 

The following are the most common causes of drug-induced urticaria antibiotics, notably penicillin (more following parenteral administration than by ingestion), barbiturates, captopril, levamisole, NSAIDs, quinine, rifampin, sulfonamides, thiopental, and vancomycin. 

The antihypertensive effects of captopril can be antagonized (reduced) by (A) Angiotensin II receptor blockers Loop diuretics NSAIDs... 

NSAIDs interfere with the antihypertensive action of angiotensin-converting enzyme inhibitors the other drugs listed enhance the blood pressure-lowering effects of captopril and other members of the pril drug family. The answer is (C). 

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