Capreolus

Antibiotic A201A. Antibiotic A201A (23), produced by S. capreolus is an /V -dimethyladenine nucleoside stmcturaHy similar to puromycin (19). Compound (23) which contains an aromatic acid and monosaccharide residues (1,4), inhibits the incorporation of amino acids into proteins but has no effect on RNA or DNA synthesis. Compound (23) does not accept polypeptides as does (19), and does appear to block formation of the initiation complex of the SOS subunit. It may block formation of a puromycin-reactive ribosome. 

Oxanosine. Oxanosiae (50), which is isolated from S. capreolus (1,148), is a potent inhibitor of GMP synthetase and nucleic acid synthesis (149,150). 

Gapreomycin, Viomycin, and Enviomycin. Capreomycin (Capastat, Lilly), a bacteriostatic, antimycobacterial peptide mixture isolated from Streptomjces capreolus was first reported in 1961 (106—108). This tuberactinomycin family member, shown in Table 4, was introduced into the U.S. market in 1971 where it has remained a usehil but nephrotoxic and ototoxic second-line alternative to first-line tuberculosis therapies. Because capreomycin is somewhat less toxic than viomycin (tuberoactinomycin B [32988-50-4]) C25H42N23O2Q (109,110), capreomycin has now displaced viomycin in the United States and most other markets. The stmcture of viomycin is shown in Figure 2. The related enviomycin (tuberactinomycin N [33103-22-9]), C23H43N23O2Q,... 

Streptomyces capreolus Capreomycin sulfate Streptomyces davuHgerus Clavulanic acid Streptomyces distallicus Stallimycin HCl Streptomyces erythreus Erythromycin Streptomyces fradiae Neomycin... 

From culture of Streptomyces capreolus by ion-exchange adsorption. Reference(s) ... 

Capreolus capreolus dwelling in a forest 35 km south-west of Paris have negative 6 N values, ranging from -2.8 to -0.4%o, probably because of local acidic soil conditions and the very territorial habits of this deer species (Rodiere et al. 1996). Such differences between habitats should be confirmed by further studies in modem imdisturbed ecosystems. This would provide a very useful framework for understanding sources of variation in Pleistocene species. 

Rodiere, E., Bocherens, FI., Angibault, J.-M. and Mariotti, A. 1996 Particularites isotopiques chez le chevreuil Capreolus capreolus L.) Implications pour les reconstitutions paleoenviron-nementales. Comptes Rendu de I Academie des Sciences de Paris 323 179-185. 

Cadmium biomagnifies in terrestrial food chains and tends to accumulate in liver and kidneys of older apex organisms (Scheuhammer 1987). This process was documented in the chain of soil to vegetation to invertebrates to upper trophic level consumers, including roe deer (Capreolus capreolus), bam owls (Tyto alba), weasels (Mystela nivalis), and kestrels (Falco tinnunculus Gorree... 

Red deer, Cervus elaphusvs. roe deer, Capreolus capreolus Slovakia, Europe... 

Lichen, Bryoria fuscescens , 37Cs June 4, 1986 Roe deer, Capreolus sp. muscle , 37Cs 1986 (post-Chernobyl)... 

Roe deer, Capreolus capreolus 137Cs muscle November 1986-February 1987 ... 

Capreomycin Capreomycin is a semisynthetic antibiotic (34.1.21) that is isolated from the cultural fluid of Streptomyces capreolus, and it is a complex of a minimum of four microbiologically active ingredients that have only partially been characterized. Capreomycins lA and IB are represented below. 

Pharmacology A polypeptide antibiotic isolated from Streptomyces capreolus. Pharmacokinetics ... 

Roadside iocation Controi area Germany 1983-86 Roe deer, Capreolus capreolus Kidney Liver... 

Roe deer, Capreolus capreo/us males, Poland 1977-78 From Hg-contaminated habitat ... 

It is a peptide protein synthesis inhibitor antibiotic isolated from Streptomyces capreolus. It is second line antimycobacterial drug which exhibits activity against human strains of Mycobacterium tuberculosis. 

Capreomycin is a peptide protein synthesis inhibitor antibiotic obtained from Streptomyces capreolus. Daily injection of 1 g intramuscularly results in blood levels of 10 mcg/mL or more. Such concentrations in vitro are inhibitory for many mycobacteria, including multidrug-resistant strains of M tuberculosis. 

Capreomycin is a mixture of cyclic polypeptides obtained from cultures of Streptomyces capreolus, and contains about 90% of capreomycins I, principally capreomycin IB (Figure 7.21). The capreomycin structures incorporate an L-capreomycidine moiety derived by cyclization of L-arginine, and three molecules of 2,3-diaminopropionic acid (Dap), which originate from serine via dehydroalanine. This antibiotic is given intramuscularly to treat tuberculosis patients who do not respond to first-line drugs, or where patients are sensitive to... 

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