Cannabinoids learning

Sullivan, J.M Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids, Learn. Mem. 2000, 7, 132-139. 

Straiker A, Mackie K (2005) Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. J Physiol 569(Pt 2) 501—17 Sullivan JM (2000) Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids. Learn Mem 7(3) 132-9 Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K, Yamashita A, Waku K (1995) 2-Arachidonoylglycerol a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 215(1) 89—97... 

Luo, J., J. H. Yin, H. Z. Wu, and Q. Wei. Extract from Fructus cannabis activating calcineurin improved learning and memory in mice with chemical drug-induced dysmnesia. Acta Pharmacol Sin 2003 24(11) 1137-1142. Degenhardt, L., W. Hall, and M. Lynskey. Exploring the association between cannabis use and depression. Addiction 2003 98(11) 1493-1504. Zajicek, J., P. Pox, H. Sanders, et al. Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study) multicentre randomised placebo-controlled trial. Lancet 2003 362(9395) 1517-1526. 

Preclinical studies have shown that fetal tetrahydro-cannabinoid levels remain lower than maternal plasma levels, indicating that the placenta may act as a partial barrier to this class of compounds. Decreased birth weight and postnatal growth have been observed in rats prenatally exposed to cannabis. Some studies have observed learning deficits in prenatally exposed animals, while others have not (Lee, 1998). 

Laviolette SR, Grace AA (2006) Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs. J Neurosci 26(24) 6458-68... 

Riedel G, Davies SN. 2005. Cannabinoid function in learning, memory and plasticity. Handb Exp Pharmacol 445—477. 

Azad SC, Eder M, Marsicano G, Lutz B, Zieglgansberger W, Rammes G (2003) Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse. Learn Mem 10 116-128... 

The cerebellum is likely to be involved in the psychoactive effects of marijuana. The effects of cannabinoids on rCBF in the cerebellum are consistent with interactions between cannabinoids and the high concentration of CBi receptors in this brain area. Both acute marijuana intoxication and habitual use have been shown to affect parameters such as motor coordination, proprioception, and learning. 

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