Cannabinoid receptor knockout mice

CBr /CB2 mice that lack CBi, CB2 or both CBi and CB2 receptors (reviewed in Howlett et al. 2002 see also the chapters by Abood and by Valverde et al., this volume). The availability of such animals provides a useful additional method for establishing whether or not responses to test compounds are CBi and/or CB2 receptor mediated and, indeed, an important means of detecting the presence of new types of cannabinoid receptor (Sect. 4.1). Cannabinoid receptor knockout mice are also being used to help determine the physiological roles of CBi and CB2 receptors. 

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Valverde O, Karsak M, Zimmer A. Analysis of the endocannabi-noid system by using CBl cannabinoid receptor knockout mice. Handb. Exp. Pharmacol. 2005 117-145. 

Di Marzo V, Breivogel CS, Tao Q, Bridgen DT, Razdan RK, Zimmer AM, Zimmer A, Martin BR (2000) Levels, metabolism, and pharmacological activity of anandamide in CBI cannabinoid receptor knockout mice evidence for non-CBl, non-CB2 receptor-mediated actions of anandamide in mouse brain. J Neurochem 75 2434-2444... 

Analysis ofthe Endocannabinoid System by Using CBi Cannabinoid Receptor Knockout Mice... 

Maccarrone M, Attina M, Bari M, Cartoni A, Ledent C, Finazzi-Agro A (2001) Anandamide degradation and N-acylethanolamines level in wild-type and CBi cannabinoid receptor knockout mice of different ages. J Neurochem 78 339-348... 

Maccarrone M, Valverde O, Barbaccia M L, Castane A, Maldonado R, Ledent C, Parmentier M, Finazzi-Agro A (2002) Age-related changes of anandamide metabolism in CBi cannabinoid receptor knockout mice correlation with behaviour. Eur J Neurosci 15 1178-1186... 

Steiner H, Bonner TI, Zimmer AM, Kitai ST, Zimmer A (1999) Altered gene expression in striatal projection neurons in CBi cannabinoid receptor knockout mice [see comments]. Proc Natl Acad Sci U S A 96 5786-5790... 

Fritzsche M. Are cannabinoid receptor knockout mice animal models for schizophrenia Med. Elypotheses 56, 638-643 (2001). 

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