Cannabinoid receptor during development

CP-55,940 (8.5) was developed during the search for novel analgesics [146]. Although it is more potent than morphine it was never approved. Nevertheless, in its tritium-labeled form it became a very important tool for research and helped in the first identification of the cannabinoid receptor. 

Berrendero, F., Garcia-Gil, L., Hernandez, M. L., Romero, J., Cebeira, M., de Miguel, R., Ramos, J. A., and Femandez-Ruiz, J. J. (1998). Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development. Development 125, 3179—3188. 

Swanson LW, McKellar S (1979) Distribution of oxytocin-stained and neurophysin-sttiined fibers in the spinal-cord of the rat and monkey. J Comp Neurol 188 87-106 Sweeney MI, White TD, Sawynok J (1987) Involvement of adenosine in the spintd tmtinociceptive effects of morphine and noradrenaline. J Pharmacol Exp Ther 243 657-665 Szabo B (2008) Pharmacology of cannabinoid receptors. Biotrend Rev 2 1—13 Szabo C (2007) Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6 917-935 Szeto HH (2003) Dynorphin and the hypothalamo-pituitary-adrenal axis during fetal development. Life Sci 73 749-758... 

Berrendero F, Sepe N, Ramos JA, Di Marzo V, Fernandez-Ruiz JJ (1999) Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period. Synapse 33 181-191... 

Most of the studies carried out on the presence and/or the activity of the components of this system during development have focused on the cannabinoid CBi receptor (Mailleux and Vanderhaeghen 1992a Romero et al. 1997 Berrendero et al. 1998 Buckley et al. 1998 Mato et al. 2003). There is also some information about the cannabinoid receptor ligands anandamide (AEA) and 2-arachidonoylglycerol (2-AG) (Berrendero et al. 1999). 

Romero J, Garcia-Palomero E, Berrendero F, Garcia-Gil L, Hernandez ML, Ramos JA, Fernandez-Ruiz JJ (1997) Atypical location of cannabinoid receptors in white matter areas during rat brain development Synapse 26 317-323... 

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