Candidate drugs to evaluate for effects on gut immune system

7 Candidate drugs to evaluate for effects on gut immune system 

Specific mefhods also exist for using the rat to evaluate the potential of drugs to cause or influence gastrointestinal inflammation and ulceration [28]. 

Gastrointestinal side effects of drugs are frequent and not limited to alterations in G1 transit or motility or histological damage observed in toxicology studies. 

Influence of drugs on mucosal barrier and particularly on paracel-lular permeability may have long-term effects on gut immune system and immune equilibrium with colonic microflora (food allergy or intolerance, leakage of immunocytes, macromolecules, bacterial infiltrations). 

Direct or indirect effects of drugs on sensitivity may trigger chronic symptoms similar to FED and particularly IBS affecting the quality of life. 

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