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Candida ergosterol

This is not discussed in detail since mechanisms of resistance have been carefully reviewed (Ghannoum and Rice 1999). It was pointed out that resistance has not been associated with modification of the structure. For the 1,2,4-triazoles that have been widely used, their effect is due to inhibition of the synthesis of ergosterol that is the dominant component of fungal cell membranes. Resistance is generally associated with modification of the target enzymes, for example, the epoxidation of squalene (Terbinafine) or 14a-demethylase (Fluconazole). Resistance of Candida albicans to the azole antifungal agent fluconazole demonstrated, however, the simultaneous occurrence of several types of mechanism for resistance (Perea et al. 2001) ... [Pg.171]

When Candida albicans was treated with bifonazole or clotrimazole, the expected accumulation of the ergosterol precursor 24-methy-lenedihydrolanosterol was observed (Figure 17). This was an indication that both compounds inhibit the cytochrome P -dependent C -demethylation. Using 2.5 ug /ml clotrimazole, dihydrolanosterol accumulates, which is known to regulate the HMG-CoA-reductase by a... [Pg.43]

Mode of action Ketoconazole interacts with C-14 a-demethylase (a cytochrome P-450 enzyme) to block demethylation of lanosterol to ergosterol, the principal sterol of fungal membranes Figure 34.4). This inhibition disrupts membrane function and increases permeability. Ketoconazole acts in an additive manner with flucytosine against Candida, but antagonizes amphotericin B s antifungal activity. [Pg.351]

Clotrimazole, as a 1% solution, is the most effective topical fungicide for the treatment of otomycosis. It is active against Aspergillus and Candida species, the most common pathogens responsible for these infections. It acts by interfering with the biosynthesis of ergosterol and is very effective for refractory or chronic cases caused by the dermatophytes or Candida species. ... [Pg.2478]

Holotoxin Ai inhibits the RNA biosynthesis in Candida albicans and Saccharomyces carlsbergensis, as indicated by the decrease in incorporation of C-uridine to the acid-insoluble fraction of the cells. Similar results were obtained for glycoside fractions of 14 species of Pacific sea cucumbers [132]. Apparently the inhibition of RNA biosynthesis in Saccharomyces carlsbergensis is related to nucleotide loss from yeast cells after treatment with glycosides. Holotoxin Ai also inhibits biosyntheses of squalene, lanosterol and ergosterol in S. carlsbergensis [133]. Mitosis is arrested and DNA synthesis inhibited in onion root bulbs by crude holothurin [134]. [Pg.176]

MacPherson, S., Akache, B., Weber, S., De Deken, X., Raymond, M., and Turcotte, B. (2005) Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes. Antimicrobial Agents and Chemotherapy, 49, 1745-1752. [Pg.187]

In fungi, increases in sterol content also increases polyene sensitivity when the yeast Schizosaccharomyces faponicus was grown aerobically it contained ergosterol and was sensitive to polyenes, but when grown anaerobically this yeast lacked sterol and became polyene-insensitive [137]. When the sterol level of Candida albicans was increased, this was accompanied by increased antibiotic sensitivity [138]. In yeasts, lowered sterol levels resulted in greater resistance to polyene antibiotics [138,139]. [Pg.118]

D. Sanglard, E Ischer, T. Parkinson, D. Ealconer, J. Bille, Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents, Antimicrob. Agents Chemother. 47 2404-2412, 2003. [Pg.347]

A. Ahmad, A. Khan, N. Manzoor, L.A. Khan, Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida, Microb. Pathog. 48 35-41, 2010. [Pg.350]

H. Van den Bossche, G. Willemsens, W. Cools, W. F. J. Lauwers and L. Le Jeune, Biochemical elfects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans, Chem. Biol. Interact., 1978, 21, 59-78. [Pg.98]


See other pages where Candida ergosterol is mentioned: [Pg.256]    [Pg.533]    [Pg.63]    [Pg.536]    [Pg.261]    [Pg.72]    [Pg.236]    [Pg.261]    [Pg.425]    [Pg.18]    [Pg.80]    [Pg.361]    [Pg.52]    [Pg.53]    [Pg.200]    [Pg.201]    [Pg.545]    [Pg.444]    [Pg.99]    [Pg.2164]    [Pg.5]    [Pg.5]    [Pg.74]    [Pg.192]    [Pg.602]    [Pg.422]    [Pg.1727]    [Pg.691]    [Pg.211]    [Pg.117]    [Pg.531]    [Pg.336]    [Pg.552]    [Pg.328]   
See also in sourсe #XX -- [ Pg.5 , Pg.886 , Pg.887 ]




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Candida

Ergosterol

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