Candida/candidosis

Odds EC. (1988) Candida and Candidosis. London Balliere Tindall. 

Miconazole is primarily used externally for Candida and dermatophyte infections of the skin and vaginal candidosis as well as for acute internal mycoses. Synonyms of this drag are acnidazil, dactar, dermonistate, and others. 

Sullivan DJ, Westerneng TJ, Haynes KA, Bennett DE, Coleman DC Candida dubliniensis sp. nov. Phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals. Microbiology 1995 141 1507-1521. 

Opportunistic Candidosis (superficial/systemic) Candida albicans Candida glabrata Candida parapsilosis... 

This drug is indicated for infections of skin and nails due to dermatophytes or Candida species and vulvovaginal infections due to Candida species. Miconazole is used orally for prophylactic purposes in patients who have been treated with cytostatics or immunosuppressants, in particular, to prevent candidosis of the mouth and digestive tract. Side effects include possible nausea during oral treatment. Miconazole tablets may increase the anticoagulant effect of coumarin derivatives. Topical treatment with cream or powder is well tolerated. Local irritation and alleigic reactions of the skin and mucosa occur only rarely. 

IC50 values of 40 pg mL 1 [6]. The SAP of C. albicans have been shown to be a major virulence factor in Candida infections [67]. Inhibition of SAP has been proposed as a new approach in the treatment of candidosis [68]. 

Candidosis refers to various forms of infection caused by the yeast Candida albicans or, occasionally, other species of Candida, A limited number of Candida infections can be directly related to the work environment. 

Candida paronychia is often difficult to treat. Topical treatment is insufficient the best therapeutic approach is intermittent (pulsed) itraconazole or fluconazole, following the schedules indicated in the treatment of dermatophyte onychomycosis. Prevention of candidosis is straightforward. It includes the avoidance of maceration at work. Chronic paronychia is best prevented by the use of appropriate gloves. The avoidance of contact with foods incriminated in the initiating protein contact dermatitis (assessed by positive prick tests) is mandatory. 

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