Candida albicans adherence

Silicone reliners are supplied as either a one-component system that cures in the presence of moisture or heat, or a two-component system containing base and catalyst. Both types adhere poody to denture base and carmot be polished satisfactorily. Some silicones support propagation of bacteria such as Candida albicans. Acrylic-based sifloxane monomers and resins have been proposed for overcoming these deficiencies (211). 

Gateau E, Levasseur P, Borgonovi M, Imbert C. (2007) The effect of aminocandin (HMR 3270) on the in vitro adherence of Candida Albicans to polystyrene surfaces coated with extracellular matrix proteins or fibronectin. Clin Microbiol Infec 13 311-315. 

Ollert MW, Sohnchen R, Korting HC, Ollert U, Brautigam S, Brautigam W Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes. Infect Immun 1993 61 4560-4568. 

Calderone RA, Braim PC Adherence and receptor relationships of Candida albicans. Microbiol Rev 1991 55 1-20. 

Sandin RL, Rogers AL, Patterson RJ, Beneke ES Evidence of mannose-related adherence of Candida albicans to human buccal epithelial cells in vitro. Infect Immun 1982 35 79-85. Douglas LJ, McCourtie J Effect of tunicamycin treatment on the adherence of Candida albicans to human buccal epithelial cells. FEMS Microbiol Lett 1983 16 199-202. 

Gaur NK, Klotz SA Ejq)ression, cloning and characterization of a Candida albicans gene, ALAI, that confers adherence properties upon Saccharomyces cerevisiae for extracellular matrix proteins. Infect Immun 1997 65 5289-5294. 

Fu Y, Rieg G, Fonzi WA, Belanger PH, Edwards JE Jr, Filler SG Expression of the Candida albicans gene ALSl in Saccharomyces cerevisiae induces adherence to endothelial and epithelial cells. Infect Immun 1998 66 1783-1786. 

Borg-von Zepelin M, Meyer I, Thomssen R, Wurzner R, Sanglard D, Telenti A, Monod M HIV-protease inhibitors reduce cell adherence of Candida albicans strains by inhibition of yeast secreted aspartic proteases. J Invest Dermatol 1999 13 747-751. 

Coagulase-negative staphylococci, such as Staphylococcus epidermidis, are the most common causes of catheter-related infections due to their ability to adhere to prosthetic material. Staphylococcus aureus, aerobic gramnegative bacilli, and Candida albicans are also common causes of catheter-related infections. Depending on local susceptibility patterns, methicillin-resistant S. aureus (MRSA) may represent up to 20% of all isolates. In contrast, upward of 80% of S. epidermidis are methicillin-resistant (MRSE). 

Cotter, G. Kavanagh, K. (2000) Adherence mechanisms of Candida albicans. Br J BiomedSci, 57,241-249. 

Mechanism of action A. Polak-Wyss ( aL. ibid. 23, 433 (1984). Inhibitory effect on germ lube formation in Candida albicans M. Schaude e( at., Mykosen 30, 28 (1987) on Candida adherence V. Vuddhakul el aL, J. Aniimicrob-Chemother. 21, 755 (1988). 

Yu, L., Lee, K. K., Hodges, R. S., Paranchych, W. and Irvin, R. T., Adherence of Pseu-domnonas aeruginosa and Candida albicans to glycosphingolipid (Asialo-GMi) receptors is achieved by a conserved receptor-binding domain present on their adhesins. Infect Immun, 1994, 62 5213-5219. 

HIV proteinase inhibitors may display a specific anti-Sap activity leading to a reduced number of C. albicans yeasts on epithelial cells. Therefore, development of specific aspartic proteinase inhibitors might be useful in the treatment of mucosal candidiasis. The precise function of Candida Saps in the adherence process is not known, but two hypotheses can be advanced (1) the Candida Saps could act as ligands to surface proteins of the specific host cells, which do... 

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