Cancer tumor suppressers

By examining some of the over one thousand tumor-causing point mutations of p53 in the light of its structure, we can identify features of p53 that are necessary for tumor suppression. The amino acids most frequently changed in cancer cells are at or near the protein-DNA interface residues that are infrequently mutated, if at all, are in general far from the DNA-binding site. 

Pestka S (2003) A dance between interferon-alpha/beta andp53 demonstrates collaborations in tumor suppression and antiviral activities. Cancer Cell 4 85-87... 

Paraneoplastic syndromes are clinical syndromes owing to nonmetastatic systemic effects of cancer. Tumors make and secrete biologically active products that can stimulate or inhibit hormone production, autoimmunity, immune complex production, or immune suppression. Lung cancer, particularly small cell lung cancer, is associated with a high rate of paraneoplastic... 

Wesley UV, Tiwari S, Houghton AN (2004) Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells. Int J Cancer 109(6) 855—866. 

Choi PM, Tchou-Wong KM, Weinstein IB (1990) Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression. Mol Cell Biol 10 4650-4657... 

Lebedeva S, Bagdasarova S, Tyler T, Mu X, Wilson DR, Gjerset RA. Tumor Suppression and Therapy Sensitization of Localized and Metastatic Breast Cancer by Adenovirus p53. Hum Gene Ther 2001 12 763-772. 

Lung cancer Human trials limited tumor suppression... 

Manipulating the genetic material by injecting tumor-suppressing genes has been an alternative way in cancer treatment. The 3p FUS1 gene is a tumor suppressor... 

The strongest risk factors for breast cancer are female gender and increasing age. Additional risk factors include endocrine factors (e.g., early menarche, nulliparity, late age at first birth, hormone replacement therapy), genetic factors (e.g., personal and family history, mutations of tumor suppresser genes [BRCAl and BRCA2]), and environmental and lifestyle factors (e.g., radiation exposure). 

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