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Monoclonal antibody therapy cancer treatment

The ground-breaking development of monoclonal antibodies by Kohler and Milstein [21] initiated the development of antibody-mediated therapeutics for cancer. Because of their unique specificity, MAb were predicted to become the magic bullets in the battle against cancer. Over the last two and a half decades MAbs have moved from clone to clinic for the treatment of various malignancies. Several MAbs are currently entering clinical trials and should appear on the market in the next few years. The first MAb for cancer therapy was approved in the US in 1997. [Pg.206]

F. Role in therapy Radioimmunotherapy is a promising new area of cancer treatment that combines the targeting power of monoclonal antibodies with the cell-damaging ability of localized radiation. When infused into a patient, these radiation-carrying antibodies circulate in the body until they locate and bind to the surface of specific cells, and then deliver their cytotoxic radiation directly to malignant cells. Zevalin is the first treatment for cancer that includes a monoclonal antibody that is combined... [Pg.312]

In recent years, a number of chelate complexes of lanthanides have been proposed for use in other fields of medical diagnosis and therapy. The complexes of Gd3+ and some heavier lanthanides with the ligands used as MRI CAs are investigated as potential CAs in radiography [3]. The complexes formed with certain radioactive isotopes, e.g. 153Sm, are used in pain palliation therapy in patients with metastatic bone cancer [4,5], while the complexes of 90Y, attached to monoclonal antibodies or certain proteins, are proposed for use in the treatment of cancer [5-7]. [Pg.104]

The first therapeutic antibody approved (Orthoclone OKT-3 or Muromonab CD3, 1986) was indicated not for cancer treatment, but for controlling acute rejection of transplanted organs (kidney, heart, and liver). Nowadays, other clinical indications such as asthma, rheumatoid arthritis, psoriasis, and Crohn s disease are treated with mAbs (see Chapter 17) (Antibody Engineering and Manufacture, 2005 Monoclonal Antibodies and Therapies, 2004 Hot Drugs, 2004 Walsh, 2004). [Pg.6]


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