Cancer, treatment biology

Pharmacogenomics of Chemotherapeutic Agents in Cancer Treatment Measurement of Natural Pyrimidines in Biological Fluids... 

Spannhoff,A.,Sippl,W.andJung,M.(2008) Cancer treatment of the future inhibitors of histone methyltransferases. The International Journal of Biochemistry ei Cell Biology, 10.1016/j.biocel.2008.1007.1024. 

APIs are chemicals that have been optimized for intended biological effect, minimal undesired side effects, and stability. Stability is essential for long shelf-life. However, this is not always successful as some APIs are also mutagenic, genotoxic, or carcinogenic, such as some compounds used in anti-cancer treatment. After their... 

Cole A (1965) The study of radiosensitive structures with low voltage electron beams. In Cellular radiation biology, Williams and Wilkins, Baltimore, pp 267-271 Cole A, Meyn RE, Chen R, Corry PM, Hittelman W (1980) Mechanisms of cell injury. In Meyn RE, Withers HR (eds) Radiation biology in cancer research, pp 33-58 Coleman CN, Bump EA, Kramer RA (1988) Chemical modifiers of cancer treatment. J Clin Oncol 6 709-733... 

PCI has been shown to increase the biological activity of a large variety of macromolecules and other molecules that do not readily penetrate the plasma membrane (Table 1). PCI has also been shown to enhance the treatment effect of targeted therapeutic macromolecules. These results show that PCI can induce efficient light-directed delivery of macromolecules into the cytosol, indicating that PCI may have a variety of useful applications for site-specific drug delivery, e.g., in gene therapy, vaccination, and cancer treatment. PCI of BLM has recently been approved for a clinical Phase I trial, where several indications have been included. The first patients with head and neck cancer have recently been treated at... 

Although structurally and spectrally similar, the differing redox and photophysical properties of the various lanthanide(III) texaphyrin complexes allow their use in such disparate areas as PDT, direct cancer treatment, and both X-ray and chemotherapy enhancement protocols. Both compounds 1 and 2 generate reactive oxygen species (ROS), albeit via mechanistically distinct pathways (vide infra). The ROS are thought to be responsible, at least in part, for the observed biological activity of MGd and MLu [22],... 

For reasons I cannot fathom, there is a new spirit of optimism in the field of cancer treatment. In the years since 1971, when the U. S. government instituted the War on Cancer , and the accumulated monies for research began to move into the tens of billions of dollars, the death rates from cancers have barely budged, despite a massive spate of clever new ideas and deeper understandings of the molecular biology, genetics and other basic sciences relevant to cancer. It should be, but is not, obvious to us by now, that cancer cures are difficult to find. 

Cameron E and Pauling L (1974b) The orthomolecular treatment of cancer. 11. Clinical trial of high dose ascorbic acid supplements in advanced human cancer. Chemical Biological Interactions 9,285-315. 

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