Cancer susceptibility genes

Miki, Y., et al., "A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1," Science, 266, 66-71 (1994). 

To identify environmental exposures which alter penetrance of cancer susceptibility genes and to quantify these gene-environment interactions. 

Shattuck-Eidens, D., et al., A collaborative survey of 80 mutations in the BRCAl breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening. Jama, 1995, 273(7), 535-41. 

Kinzler KW, Vogelstein B (1997) Cancer-susceptibility genes. Gatekeepers and caretakers. Nature... 

Landers and co-workers compared various surface derivatization agents in conjunction with coating polymers for DNA heteroduplex analysis of the breast cancer susceptibility gene (BRCA1) [29]. The most effective coating combina-... 

Roberts, L. (1993). Zeroing in on the breast cancer susceptibility gene. Science 259, 622 625. 

Allain LR, Vo-Dinh T (2002) Surface-enhanced Raman scattering detection of the breast cancer susceptibility gene BRCAl using a silver-coated microarray platform. Anal Chim Acta 469 149-154... 

Shields PG, Bowman ED, Harrington AM, Doan VT, Weston A. 1993. Polycyclic aromatic hydrocarbon-DNA adducts in human lung and cancer susceptibility genes. Cancer Res. 53 3486-92... 

Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA 1. Science 1994 266 66-71. 

Wooster R, Neuhausen SL, Mangion J, et al. Localization of a breast cancer susceptibility gene, BRCA 2, to chromosome 13ql2-13. Science 1994 265 2088-90. 

Chen ST, Chen RA, Kuo SJ, Chien YC. Mutational screening of breast cancer susceptibility gene 1 from early onset, bi-lateral, and famihal breast cancer patients in Taiwan. Breast Can Res Treat 2003 77 133-43. 

Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 1995 378 789-92. 

L. C. Brody and B. B. Biesecker Breast cancer susceptibility genes BRCAl and BRCA2. Medicine 77, 208 (1998). 

TCR refers to a repair pathway that preferentially and rapidly repairs lesions on the transcribed strand of active genes (less than 1% of human DNA) [47,48]. In TCR-NER the ability of a lesion to block RNA polymerases seems critical. The stalled polymerase recruits at least two TRC-specific factors CSA and CSB. The remainder of the TCR-NER pathway (i.e., unwinding, incision, excision, DNA synthesis, and ligation) may be identical to the GGR-NER pathway. The breast and ovarian cancer susceptibility gene BRCAl is involved in TCR [49,50] however, the exact biological function of the protein remains uncertain (for review see [51]). 

Interestingly, the tumor suppressor breast cancer susceptibility gene 1 (BRCAl) can bind the phosphorylated inactive ACC to prevent re-activation (Moreau et al., 2006). In addition, squamous cell carcinomas of the lung show lower immunohistochemical staining of phosphorylated inactive ACC than adenocarcinoma with poor prognosis (Conde et al., 2007). The strong... 

This may be especially attractive to persons carrying known cancer-susceptibility genes. The S5mthetic antiestrogen tamoxifen is being evaluated as a chemopreventive agent for breast cancer. However, a planned large-scale trial was postponed because of uncertainities about safety. ... 

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