Mutation cancer

As mentioned earlier, cancerous mutations can occur as a result of oxidative damage to DNA caused by free radicals generated as a damaging side-effect... [Pg.32]

Steele VE, Hawk ET, Viner JL and Lubet RA. 2003. Mechanisms and applications of nonsteroidal antiinflammatory drugs in the chemoprevention of cancer. Mutat Res 523-524 137-144. [Pg.174]

Ames, B.N., DNA damage from micronutrient deficiencies is likely to be a major cause of cancer, Mutat. Res., 475, 7, 2001. [Pg.313]

Denissenko MF, Pao A, Tang M, Pfeifer GP. (1996). Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science. 274(5286) 430-32. [Pg.449]

H. Bernstein, C. Bernstein, C. M. Payne, K. Dvorakova and H. Garewal, Bile acids as carcinogens in human gastro-intestinal cancers, Mutation Res., 2005, 589, 47. [Pg.95]

Kundu JK, Surh Y-J. 2008b. Inflammation Gearing the journey to cancer. Mutat Res 659 15-30. [Pg.354]

Colorectal cancer Mutation KRAS EGFR Cetuximab, Panitumumab... [Pg.51]

Non-small cell lung cancer Mutation EGFR EGFR (tyrosine-kinase activity) Erlotinib, Gefitinib... [Pg.51]

Nebert DW. The Ah locus genetic differences in toxicity, cancer, mutation, and birth defects. Crit Rev Toxicol 1989 20 153-174. [Pg.194]

Mitochondrial Disease and Cancer Mutations in the genes that encode certain mitochondrial proteins are associated with a high incidence of some types of cancer. How might defective mitochondria lead to cancer ... [Pg.216]

Toquet C, Toussaint G, Letalaer JY. 1981. Studies on mutagenic constituents of apple brandy and various alcoholic beverages collected in western France, a high incidence area for esophageal cancer. Mutat Res 88 155-164. [Pg.129]

We often want to prevent or retard free-radical reactions. For example, oxygen in the air oxidizes and spoils foods, solvents, and other compounds mostly by free-radical chain reactions. Chemical intermediates may decompose or polymerize by free-radical chain reactions. Even the cells in living systems are damaged by radical reactions, which can lead to aging, cancerous mutations, or cell death. [Pg.161]

DOT CLASSIFICATION 5.1 Label Oxidizer SAFETY PROFILE Poison by ingestion. Human systemic effects tinnitus, pulse rate increase, blood pressure lowering. Experimental teratogenic and reproductive effects. Nitrites have been implicated in an increased incidence of cancer. Mutation data reported. Flammable when exposed to heat or flame. A powerful oxidizing material. Slight explosion hazard when exposed to heat. It win explode at 1000°F. Explosive... [Pg.1165]

Marcz5mski B, Kraus T, Rozynek P, et al. 2000a. Association between 8-hydroxy-2 -deoxyguanosine levels in DNA of workers highly exposed to asbestos and their clinical data, occupational and non-occupational confounding factors, and cancer. Mutat Res 468 203-212. [Pg.299]

B.N. Ames and L.S. Gold. 1991. Endogenous mutagens and the causes of aging and cancer Mutat. Res. 250 3-16. (PubMed)... [Pg.1157]

Mutations in p53 occur in about half of all human cancers, including colorectal cancer. Mutations in p53 constitute a necessary step in the conversion of many types of normal cells to invasive CBincer cells. Tlie defect in p53 increases the rate of accumulation of mutations in many other genes. Perhaps one of these mutations... [Pg.892]

Mutations in RAS are common in various types of cancer. Mutations in RAS can result in an inability to hydrolyze GTP, with the following consequence RAS is maintained in Us active form, cell sign ihng is constitutive (rather than momentary), and the cell is provoked to divide and grow continuously. [Pg.902]

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