Cancer chemoprevention curcumin

Ireson, C. R. et al., Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine, Cancer Epidemiol. Biomarkers Prev., 11, 105, 2002. 

Chearwae, W. et al.. Modulation of the function of the multidrug resistance-linked ATP-binding transporter ABCG2 by the cancer chemopreventive agent curcumin. Mol. Cancer Then, 5, 1995, 2006. 

Thangapazham RL, Sharma A, Maheshwari RK. 2006. Multiple molecular targets in cancer chemoprevention by curcumin. APPS J 8 443-449. 

Shen G, Xu C, Hu R, Jain MR, Gopalkrishnan A, Nair S, Huang MT, Chan JY, Kong AN. 2006. Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin. Mol... 

Lin C-L, Lin J-K. (2008) Curcumin A potential cancer chemopreventive agent through suppressing NF-kB signaling. J Cancer Molecules 4 11-16. 

Singh S, Khar A. Biological effects of curcumin and its role in cancer chemoprevention and therapy. Anticancer Agents Med. Chem. 2006 6 259-270. 

Recently, Youssef et al. [24] reported the synthesis of curcumin analogs as potential antioxidant and cancer chemopreventive agents. The general structures of the synthesized analogs are shown in Fig. (8). These compounds were tested for scavenging ability of DPPH free radicals and in an ATP chemiluminescence assay. The SAR conclusions from the results were mainly consistent with the prior conclusions drawn by other researchers. In addition, they found that di-substitution of the central methylene group resulted in decreased antioxidative activity. 

Samaha HS, Kelloff GJ, Steele V, Rao CV, Reddy BS. Modulation of apoptosis by sulindac, curcumin, phenylethyL3-methylcaffeate, and 6-phenylhexyl isothiocyanate apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res 1997 57 1301-1305. 

Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin. Mol Cancer Ther... 

Several in vivo studies have established the chemopreventive as well as anticancer effect of curcumin against a variety of cancers, as summarized in... 

Table 16.1 Curcumin Exhibits Chemopreventive and Anticancer Effects Against Various Cancers...

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