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Cancer apoptosis proteins

Nachmias, B., Ashhab, Y., Ben-Yehuda, D. (2004) The inhibitor of apoptosis protein family (IAPs) an emerging therapeutic target in cancer. Semin Cancer Biol 14, 231-243. [Pg.276]

Yang L, et al. Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460... [Pg.182]

Fig. 13.10 Caspase activation by extrinsic and intrinsic apoptotic pathways, (a) Extrinsic path. This path is mediated by members of the tumor necrosis factor (TNF) superfamily (see text), (b) Intrinsic pathway. This path may be mediated by various physiological or pathological changes, but only the modes of induction of this path in periodontitis are discussed (see text). Details of cytochrome c release and caspase activation are shown in Fig. 13.11 (This figure is modified from Fig. 1 in Schimmer AD (2004 Oct 15) Inhibitor of Apoptosis Proteins Translating Basic Knowledge into Clinical Practice. Cancer Research, 64 7183-7190)... Fig. 13.10 Caspase activation by extrinsic and intrinsic apoptotic pathways, (a) Extrinsic path. This path is mediated by members of the tumor necrosis factor (TNF) superfamily (see text), (b) Intrinsic pathway. This path may be mediated by various physiological or pathological changes, but only the modes of induction of this path in periodontitis are discussed (see text). Details of cytochrome c release and caspase activation are shown in Fig. 13.11 (This figure is modified from Fig. 1 in Schimmer AD (2004 Oct 15) Inhibitor of Apoptosis Proteins Translating Basic Knowledge into Clinical Practice. Cancer Research, 64 7183-7190)...
Diverse drug targets in this field are at an early stage of development, such as endogenous inhibitors of apoptosis proteins (lAP), a family of caspase inhibitors that selectively bind and inhibit caspases-3, -7, and -9. The inhibition of these lAP might stimulate apoptosis of cancer cells with potential as a treatment of malignancy. ... [Pg.98]

Dean, E. J., Ranson, M., Blackball, R, Holt, S. V, Dive, C. Novel therapeutic targets in lung cancer inhibitor of apoptosis proteins from laboratory to clinic. Cancer Treat. Rev. 2007, 33, 203-212. [Pg.105]

Gaither A, Porter D, Yao Y et al (2007) A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Res 67 11493-11498... [Pg.54]

Vucic D, Fairbrother WJ (2007) The inhibitor of apoptosis proteins as therapeutic targets in cancer. Clin Cancer Res 13(20) 5995-6000... [Pg.100]

Vucic D (2008) Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors. Curr Cancer Drug Targets 8(2) 110-117... [Pg.100]

Sasaki H, Sheng Y, Kotsuji F et al (2000) Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res 60(20) 5659-5666... [Pg.101]

Cai Q, Sun H, Peng Y et al (2011) A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem 54(8) 2714-2726... [Pg.103]

Cummings, J., Ward, T.H., LaCasse, E., Lefebvre, C., St Jean, M., Durkin, J., Ranson, M., and Dive, C. (2005) Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X linked inhibitor of apoptosis protein XIAP. British Journal of Cancer, 92, 532 538. [Pg.160]

Yamagiwa, Y., Marienfeld, C., Meng, F., Holcik, M., and Patel, T. Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6 A novel mechanism of tumor cell survival. Cancer Res 64, 1293-1298 (2004). [Pg.150]

Table 2 Select anti-cancer agents targeting inhibitor of apoptosis proteins... [Pg.161]

Rohayem J, Diestelkoetter P, Weigle B et al. Antibody response to the tumor-associated inhibitor of apoptosis protein in cancer patients. Cancer Res 2000 60 1815-1817. [Pg.182]

Because Survivin, a member of the inhibitor of apoptosis protein (lAP) family, is highly expressed in most tumors, it has been recognized as a promising therapeutic target in cancer [99]. A variety of Survivin antagonists have been reported to rescue the apoptotic pathway and induce apoptosis in... [Pg.308]

ALG-2 is the fust calcium-binding protein of the EF-hand family found to be directly involved in apoptosis. ALG-2 is a 22 kDa protein and like the other members of the penta EF-hand family, contains five EF-hands, with only two of them functional. ALG-2 protein is expressed in the brain and eye and was found to be upregulated in various cancer tissues. Several targets have been found, such as proteins AEP, Alix, preflin, and annexins, suggesting a putative role of ALG-2 in apoptosis. [Pg.294]

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See also in sourсe #XX -- [ Pg.145 ]



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Cancer apoptosis

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