RGD-containing cyclic peptides

For this review we have selected the cyclic modified peptides mentioned above, i.e. vancomycin, nisin, cyclosporin, and cyclotheonamide, as well as two examples, i.e. RGD-containing cyclic peptides and SH2 domain binding cyclic peptides, which were inspired by proteins. 

Fig. 4 Structures of DTPA- and D OTA-conjugated integrin av/ 3 receptor antagonists (RGD-containing cyclic peptides)...

Several potent inhibitors of fibrinogen binding to gpIIb/IIIa are now known, and some have proven to be effective antithrombotic agents. These inhibitors tend either to be small cyclic peptide mimetics, in which the conformation of an RGD sequence is constrained by macrocyclization, or they are non-peptidic molecules containing functional group mimetics of the Arg and Asp side chains, held in the correct geometry for interaction with the receptor. Examples of both classes are shown in... 

Several approaches to cyclic RGD-containing peptides have heen... 

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